Reducing bone lead content by chelation treatment in chronic lead poisoning: an in vivo X-ray fluorescence and bone biopsy study.
Reducing bone lead content by chelation treatment in chronic lead poisoning: an in vivo X-ray fluorescence and bone biopsy study.
复制标题
通过螯合治疗降低慢性铅中毒的骨铅含量：体内 X 射线荧光和骨活检研究。
DOI：
10.1016/s0013-9351(89)80086-6
复制
发表时间：
1989
影响因子：
8.3
通讯作者：
Schidlovsky,G
中科院分区：
文献类型：
--
作者：
Batuman,V;Wedeen,RP;Bogden,JD;Balestra,DJ;Jones,K;Schidlovsky,G
一位长期接触铅的彩色玻璃艺术家出现了神经精神症状。通过CaNa2EDTA铅动员试验、髂嵴骨铅测量和体内胫骨X射线荧光（XRF）评估患者在螯合治疗前后的情况。这三种方法显示，在螯合治疗期间，体内铅储存量逐渐下降，与症状改善以及血铅和锌原卟啉水平下降相关。体内胫骨XRF是一种安全、快速且非侵入性的技术，可用于检测体内铅负荷过多。骨铅含量的XRF测量是监测治疗效果以及建立诊断的实用方法。
A stained-glass artist with longstanding exposure to lead presented with neuropsychiatric symptoms. He was evaluated before and after chelation treatment by the CaNa2EDTA lead mobilization test, iliac crest bone lead measurement, andin vivotibial X-ray fluorescence (XRF). The three methods showed a progressive fall in body lead stores during chelation therapy in association with improvement in symptoms and a fall in blood lead and zinc protoporphyrin levels.In vivotibial XRF is a safe, rapid, and noninvasive technique for detecting excessive body lead burdens. XRF measurement of bone lead content is a practical method for monitoring the efficacy of therapy as well as for establishing the diagnosis.