Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN
Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN
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DOI：
10.1007/s11033-011-1190-7
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发表时间：
2012-04-01
影响因子：
2.8
通讯作者：
Lee, Chaeyoung
中科院分区：
文献类型：
--
作者：
Oh, Dongyep;Lee, Yoonseok;Lee, Chaeyoung
以513头韩国牛为研究样本，研究了脂肪酸组成与脂肪酸合成酶基因外显子单核苷酸多态性（snp）的遗传关系。g.12870的5个单核苷酸多态性T b> C, g.13126C、g.15532A、g.16907T > C和g.17924G > A与各种脂肪酸组成相关，与大理石纹评分相关（P < 0.05）。CC、TT、AA、TT、GG基因型与单不饱和脂肪酸增加、饱和脂肪酸减少相关（P < 0.05）。各snp基因型均显著提高大理石纹评分（P < 0.05）。进一步与脂肪酸组成的遗传关联表明，在g.15532、g.16907和g.17924位点与ATG单倍型纯合的基因型增加了单不饱和脂肪酸和大理石纹评分（P < 0.05）。结果表明，FASN基因中g.12870、g.13126、g.15532、g.16907和g.17924的5个外显子snp可以改变脂肪酸含量。它们的CC、TT、AA、TT、GG基因型和g.15532、g.16907、g.17924单倍型被推荐用于牛肉品质遗传改良。
Genetic associations of fatty acid composition with exonic single nucleotide polymorphisms (SNPs) in the gene encoding fatty acid synthase (FASN) were examined using 513 Korean cattle. All five individual SNPs of g.12870 T > C, g.13126 T > C, g.15532 C > A, g.16907 T > C and g.17924 G > A were associated with a variety of fatty acid compositions and further with marbling score (P < 0.05). Their genotypes of CC, TT, AA, TT, and GG were associated with increased monounsaturated fatty acids and with decreased saturated fatty acids (P < 0.05). The genotypes at all the SNPs also increased marbling score (P < 0.05). Further genetic associations with fatty acid composition suggested that homozygous genotype with the haplotype of ATG at g.15532, g.16907, and g.17924 in a linkage disequilibrium block increased monounsaturated fatty acids and marbling score (P < 0.05). We concluded that the five exonic SNPs of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents. Their genotypes of CC, TT, AA, TT, and GG and haplotype of ATG at g.15532, g.16907, and g.17924 were recommended for genetic improvement of beef quality.