PCPT: Evidence That Finasteride Reduces Risk of Most Frequently Detected Intermediate- and High-grade (Gleason Score 6 and 7) Cancer
PCPT: Evidence That Finasteride Reduces Risk of Most Frequently Detected Intermediate- and High-grade (Gleason Score 6 and 7) Cancer
复制标题
DOI：
10.1016/j.urology.2008.09.079
复制
发表时间：
2009-05-01
期刊：
影响因子：
2.1
通讯作者：
Vaughan, E. Darracott, Jr.
中科院分区：
文献类型：
--
作者：
Kaplan, Steven A.;Roehrborn, Claus G.;Vaughan, E. Darracott, Jr.
目的通过对前列腺癌预防试验中指定的、探索性的、活组织的抽样密度调整后的分析进行后期推广，确定非那雄胺与安慰剂相比对前列腺癌(PCA)风险的影响。
OBJECTIVES To determine the effect of finasteride relative to placebo on prostate cancer (PCa) risk at each individual Gleason score in the Prostate Cancer Prevention Trial using a post hoc generalization of a prespecified, exploratory, biopsy sampling density-adjusted analysis.METHODS The Prostate Cancer Prevention Trial enrolled 18 882 men aged >= 55 years with a prostate-specific antigen level of