Long-term outcome of HBV carriers with negative HBe antigen and normal aminotransferase
Long-term outcome of HBV carriers with negative HBe antigen and normal aminotransferase
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DOI：
10.1016/j.amjmed.2006.04.036
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发表时间：
2006-11-01
影响因子：
5.9
通讯作者：
Kumada, Hiromitsu
中科院分区：
文献类型：
--
作者：
Ikeda, Kenji;Arase, Yasuji;Kumada, Hiromitsu
医生：为了阐明的发病率肝炎活化和肝细胞癌的患者与阴性HBe抗原和正常转氨酶，长期观察进行了回顾性coherent.METHODS：在116例连续正常转氨酶和阴性HBe抗原在肝活检时，连续冷冻血清最初5年的95例患者。结果：肝活检显示轻度肝炎（F0）9例，F1 53例，F2 21例，F3 6例，F4或肝硬化6例。33例患者的初始HBV DNA浓度较低（低于10（4）拷贝/ mL），53例患者的初始HBV DNA浓度中等（10（4）- 10（6）），9例患者的初始HBV DNA浓度较高（10（6）或以上）。在第三年结束时，低DNA组的肝炎活化率为正常转氨酶的两倍，中等DNA组为43.4%，高DNA组为66.7%。初始HBV DNA值与将来转氨酶升高显著相关（P
PURPOSES: To elucidate the incidence of hepatitis activation and hepatocellular carcinogenesis in patients with negative HBe antigen and normal aminotransferase, long-term observation was performed in a retrospective cohort.METHODS: Among 116 consecutive patients with normal aminotransferase and negative HBe antigen at the time of liver biopsy, sequential frozen sera for initial 5 years were available for 95 patients. Hepatitis B virus ( HBV) DNA assay ( sensitivity > 400 copy/ mL) and aminotransferase were annually examined in the initial 5 years after biopsy.RESULTS: Liver biopsy showed minimal hepatitis ( F0) in 9, F1 in 53, F2 in 21, F3 in 6, and F4 or cirrhosis in 6. Initial HBV DNA concentration was low ( less than 10(4) copies/ mL) in 33, intermediate ( 10(4)- 10(6)) in 53, and high (10(6) or more) in 9. Hepatitis activation rates with twice as high as normal aminotransferase at the end of the third year were 12.1% in the low DNA group, 43.4% in the intermediate group, and 66.7% in the high DNA group. Initial HBV DNA values were significantly associated with future increase in aminotransferase ( P