Immunological changes in young and old adults during brief laboratory stress.
Immunological changes in young and old adults during brief laboratory stress.
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DOI：
10.1097/00006842-199103000-00002
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发表时间：
1991-03
影响因子：
3.3
通讯作者：
B. Naliboff;D. Benton;G. Solomon;J. Morley;J. Fahey;E. Bloom;T. Makinodan;S. Gilmore
中科院分区：
文献类型：
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作者：
B. Naliboff;D. Benton;G. Solomon;J. Morley;J. Fahey;E. Bloom;T. Makinodan;S. Gilmore
几乎没有关于人类免疫系统在受控实验室条件下对急性心理应激源的反应的数据。年轻女性受试者(21-41岁)在短暂(12分钟)应激性心算检查后，自然杀伤(NK)细胞活性、循环CD8抑制/细胞毒性T细胞和自然杀伤淋巴细胞数量增加。年龄较大的女性受试者(65-85岁)未表现出与应激相关的NK活性增加。心理应激导致老年人外周血中CD8抑制/细胞毒性T细胞和NK细胞数量增加，其程度与青年组相似。两组受试者的辅助性/诱导性T细胞(CD_4)、总T细胞(CD_3)或B细胞(CD_(20))在应激源作用下均无明显变化。两个年龄组的心血管、儿茶酚胺和主观应激反应相似。这些结果表明，短暂的心理应激与一些快速的免疫细胞变化有关，包括CD8抑制/细胞毒性T细胞和NK细胞释放到循环中，在年轻人中，NK活性增加。老年受试者未见NK细胞活性增加，提示应激对NK细胞的动员和细胞溶解可能有不同程度的影响。结果还表明，在某些环境要求下，NK活性的上调可能存在与年龄相关的缺陷。
&NA; Few data are available on the response of the human immune system to acute psychological stressors under controlled laboratory conditions. Young female subjects (21–41 years) showed increases in natural killer (NK) cell activity, and in the numbers of circulating CD8 suppressor/cytotoxic T cells, and natural killer lymphocytes following a brief (12 minute) stressful mental arithmetic examination. Older female subjects (65–85 years) failed to show the stress‐related increase in NK activity. The psychological stress did lead to increases in the numbers of circulating CD8 suppressor/cytotoxic T cells and NK lymphocytes in old subjects to a similar degree as that seen in the young group. No changes in the numbers of helper/inducer T cells (CD4), total T cells (CD3), or B cells (CD20) were found following the stressor for either group. Cardiovascular, catecholamine, and subjective stress responses were similar for the two age groups. These results demonstrate that brief psychological stress is associated with some rapid immune cell changes, including release of CD8 suppressor/cytotoxic T cells and NK cells into circulation, and in young subjects, increases in NK activity. The absence of an NK activity increase in the older subjects indicates that NK cell mobilization and cell lysis induced by NK cells may be differentially affected by stress. The results also suggest the possibility of an age‐related deficit in the up‐regulation of NK activity under some environmental demands.