UPTAKE AND BIODISTRIBUTION OF DOPAMINE IN BONE-MARROW, SPLEEN AND LYMPH-NODES OF NORMAL AND TUMOR-BEARING MICE
UPTAKE AND BIODISTRIBUTION OF DOPAMINE IN BONE-MARROW, SPLEEN AND LYMPH-NODES OF NORMAL AND TUMOR-BEARING MICE
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DOI：
10.1016/0024-3205(93)90645-j
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发表时间：
1993-01-01
期刊：
影响因子：
6.1
通讯作者：
CHOWDHURY, JR
中科院分区：
文献类型：
--
作者：
BASU, S;DASGUPTA, PS;CHOWDHURY, JR
在正常小鼠宿主的骨髓、脾脏和淋巴结中，体内标记的多巴胺摄取明显。相反，动物携带固体埃利希癌，H-3-多巴胺摄取显着减少。肿瘤组织本身仅含有微量的多巴胺。骨髓细胞、脾细胞和淋巴结淋巴细胞对该单胺有特异性摄取。目前，多巴胺在调节心脏和肾脏功能中的外周作用已得到充分证实，并在临床上用于治疗充血性心脏和肾衰竭。骨髓、脾脏和淋巴结对多巴胺的特异性摄取，以及肿瘤生长后造血和免疫功能被破坏的改变，这一结果加强了我们以前的观点，即多巴胺也可能影响这些外周器官的功能。了解DA对这些外周器官的可能影响可能对血液学和免疫异常的管理具有未来的临床意义。
Significant labelled dopamine uptake was evident in bone marrow, spleen and lymph nodes of normal murine hosts-in vivo. On the contrary animals bearing solid Ehrlich carcinoma, H-3-dopamine uptake was significantly reduced. The tumor tissue itself incorporated only insignificant amount of dopamine. Bone marrow cells, splenocytes and lymphocytes from lymph nodes showed specific uptake of this monoamine. At present the peripheral role of dopamine in the regulation of heart and kidney functions are well documented and utilized clinically for treatment of congestive heart and renal failure. The present result of specific dopamine uptake by bone marrow, spleen and lymph nodes and alterations following tumor growth where hematopoesis and immune functions are disrupted, strengthens our previous idea that dopamine might also influence the functions of these peripheral organs. Knowledge of this possible effect of DA on these peripheral organs may be of future clinical significance in the management of hematological and immune abnormalities.