Dorsal root vasodilatation in cat skeletal muscle.
Dorsal root vasodilatation in cat skeletal muscle.
复制标题
猫骨骼肌的背根血管舒张。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
J. Marshall
中科院分区：
文献类型：
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作者：
S. Hilton;J. Marshall
1.在氯醛糖麻醉的猫上，研究了逆行刺激背根L6-S1对腓肠肌血流量的影响。2.用0.3-0.5毫秒的脉冲电流刺激结扎的背根的外周端，以最有效地激活较小的传入纤维的强度刺激15-20秒，可使肌肉血管传导性增加50-60%，起效缓慢，持续时间长于刺激。3.这种肌肉血管扩张作用可在瘫痪动物身上引起，但不受胍乙胺和阿托品的影响。然而，前列腺素合成酶抑制剂吲哚美辛或乙酰水杨酸对局部注射乙酰胆碱所产生的扩张或肌肉收缩引起的功能性充血没有影响，这种作用被大大减少，甚至被取消。4.结论是，骨骼肌较小的有髓或无髓传入纤维的活动导致肌肉血流量增加，这至少部分是由肌肉内局部合成的前列腺素介导的。
1. A study has been made, in the cat anaesthetized with chloralose, of the effects of antidromic stimulation of dorsal roots L6‐S1 on the blood flow through the gastrocnemius muscle. 2. Stimulation of the peripheral ends of the ligated dorsal roots with current pulses of 0.3‐0.5 msec duration and at intensities most effective in activating the smaller afferent fibres, for periods of 15‐20 sec, produced a 50‐60% increase in muscle vascular conductance which was slow in onset and long outlasted the stimulus. 3. This muscle vasodilatation could be evoked in the paralysed animal and was unaffected by guanethidine or atropine. It was, however, greatly reduced or even abolished by the prostaglandin synthetase inhibitors, indomethacin or acetylsalicylic acid, in doses which had no effect on the dilatation produced by a local injection of acetylcholine or the functional hyperaemia induced by muscle contraction. 4. It is concluded that activity in the smaller myelinated or unmyelinated afferent fibres of skeletal muscle produces an increase in muscle blood flow which is mediated, at least in part, by prostaglandins locally synthesized within the muscle.