Facile preparation of the N‐acetyl‐glucosaminylated asparagine derivative with TFA‐sensitive protecting groups useful for solid‐phase glycopeptide synthesis
Facile preparation of the N‐acetyl‐glucosaminylated asparagine derivative with TFA‐sensitive protecting groups useful for solid‐phase glycopeptide synthesis
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轻松制备具有 TFA 敏感保护基的 N-乙酰氨基葡萄糖化天冬酰胺衍生物，可用于固相糖肽合成
DOI：
10.1002/psc.2792
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发表时间：
2015
影响因子：
2.1
通讯作者：
H. Katayama
中科院分区：
文献类型：
--
作者：
H. Katayama
在这项研究中，开发了一种新型的N-乙酰基-氨基葡萄糖化天冬酰胺衍生物。该衍生物带有 TFA 敏感的保护基团，并且仅通过三个步骤从市售化合物衍生而来。它适用于普通的基于9-芴基甲氧基羰基（Fmoc）的固相肽合成（SPPS）方法，并且可以通过通常用于Fmoc-SPPS最终脱保护步骤的TFA鸡尾酒处理的一步去除碳水化合物部分上的保护基。版权所有 © 2015 欧洲肽协会和 John Wiley & Sons, Ltd.
In this study, a novel N‐acetyl‐glucosaminylated asparagine derivative was developed. This derivative carried TFA‐sensitive protecting groups and was derived from commercially available compounds only in three steps. It was applicable to the ordinary 9‐fluorenylmethoxycarbonyl (Fmoc)‐based solid‐phase peptide synthesis (SPPS) method, and the protecting groups on the carbohydrate moiety could be removed by a single step of TFA cocktail treatment generally used for the final deprotection step in Fmoc‐SPPS. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.
影响因子：
4.8
作者：
Umekawa, Midori;Huang, Wei;Yamamoto, Kenji
通讯作者：
Yamamoto, Kenji