Motor skill learning is associated with diffusion characteristics of white matter in individuals with chronic stroke.
Motor skill learning is associated with diffusion characteristics of white matter in individuals with chronic stroke.
复制标题
DOI：
10.1097/npt.0b013e3182a3d353
复制
发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Boyd LA
中科院分区：
文献类型：
--
作者：
Borich MR;Brown KE;Boyd LA
成像技术的进步使得研究中风后的白色物质成为可能;越来越多的文献显示了白色物质微结构的弥散测量与运动功能之间的联系。然而，这些措施和运动技能学习之间的关系还没有被认为是在个人中风。本研究的目的是调查慢性卒中患者的内囊同侧后肢（PLIC）内的扩散张量成像（DTI）所指示的训练后白色微结构状态与学习新运动任务之间的关系。13名慢性中风患者和9名健康对照者在5次会议上进行了视觉追踪任务。与学习相关的运动行为的变化通过比较基线表现与延迟保持测试来索引。分数各向异性（FA）指数在保留测试是主要的DTI衍生的结果措施。在慢性卒中患者中，我们发现训练后同病灶PLIC FA与运动学习相关变化幅度之间存在关联;分层多元线性回归分析显示，年龄、卒中后时间和训练后同病灶PLIC FA的组合与运动学习相关变化相关（R2=0.649，p=0.02）。基线运动表现与训练后同病灶PLIC FA无关。训练后同病灶PLIC的扩散特征与熟练运动行为的变化幅度有关。这些结果意味着，局部白色物质的微结构特性指数的扩散行为可能是一个重要的因素，以考虑当确定潜在的反应，以康复中风的人。提供视频摘要（参见视频，补充数字内容1。）从作者那里获得更多见解。
Imaging advances allow investigation of white matter following stroke; a growing body of literature has shown links between diffusion-based measures of white matter microstructure and motor function. However, the relationship between these measures and motor skill learning has not been considered in individuals with stroke. The aim of this study was to investigate the relationships between post-training white matter microstructural status, as indexed by diffusion tensor imaging (DTI) within the ipsilesional posterior limb of the internal capsule (PLIC) and learning of a novel motor task in individuals with chronic stroke. Thirteen participants with chronic stroke and nine healthy controls practiced a visuomotor pursuit task across five sessions. Change in motor behavior associated with learning was indexed by comparing baseline performance with a delayed retention test. Fractional anisotropy (FA) indexed at the retention test was the primary DTI-derived outcome measure. In individuals with chronic stroke, we discovered an association between post-training ipsilesional PLIC FA and the magnitude of change associated with motor learning; hierarchical multiple linear regression analyses revealed that the combination of age, time post stroke and ipsilesional PLIC FA post-training was associated with motor learning related change (R2=0.649, p=0.02). Baseline motor performance was not related to post-training ipsilesional PLIC FA. Diffusion characteristics of post-training ipsilesional PLIC were linked to magnitude of change in skilled motor behavior. These results imply that the microstructural properties of regional white matter indexed by diffusion behavior may be an important factor to consider when determining potential response to rehabilitation in persons with stroke. Video Abstract available (See Video, Supplemental Digital Content 1.) for more insights from the authors.