A novel apparatus for measuring rat locomotor behavior.
A novel apparatus for measuring rat locomotor behavior.
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一种测量大鼠运动行为的新型装置。
DOI：
10.1016/0165-0270(94)00145-7
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发表时间：
1995
影响因子：
3
通讯作者：
Nash,JF
中科院分区：
文献类型：
--
作者：
Brodkin,J;Nash,JF
设计了一种新颖、廉价的装置（轨迹计）来测量大鼠的行为活动，包括总体运动活动、饲养和运动模式的结构特征（即分形维数）。测量在 3 个维度上进行，分辨率约为 1 厘米。为了测试系统的敏感性和特异性，对大鼠施用盐水或 d-苯丙胺（0.5、1、2 和 4 mg/kg，腹腔注射），并分析运动活动、后立和计算为分形维数的运动行为结构。使用定位仪获得的结果与之前使用其他设备测量基础和兴奋剂诱导的行为（即红外光束、视觉观察、视频跟踪等）的报告一致。基于这些数据，本文描述的新型装置为分析大鼠的运动行为提供了灵敏、通用且廉价的工具。
A novel, inexpensive apparatus (locometer) was designed to measure behavioral activity of rats including gross locomotor activity, rearing, and structural characteristies of movement patterns (i.e., fractal dimension). Measurements were done in 3 dimensions at a resolution of approximately 1 cm. To test the sensitivity and specificity of the system, saline or d-amphetamine (0.5, 1, 2, and 4 mg/kg, i.p.) was administered to rats and locomotor activity, rearing and the structure of motor behavior calculated as the fractal dimension, were analyzed. The results obtained with the locometer were consistent with previous reports using other devices to measure basal and stimulant-induced behavior (i.e., infrared photobeam, visual observation, video tracking, etc.). Based on these data, the novel apparatus, described herein, provides a sensitive, versatile, and inexpensive tool for the analysis of locomotor behavior in the rat.