The ocular effects of intracarotid bromodeoxyuridine and radiation therapy in the treatment of malignant glioma.
The ocular effects of intracarotid bromodeoxyuridine and radiation therapy in the treatment of malignant glioma.
复制标题
颈动脉内溴脱氧尿苷和放射治疗治疗恶性胶质瘤的眼部效果。
DOI：
10.1016/s0161-6420(90)32593-9
复制
发表时间：
1990
期刊：
影响因子：
13.7
通讯作者：
Greenberg,HS
中科院分区：
文献类型：
--
作者：
Vander,JF;Kincaid,MC;Hegarty,TJ;Page,M;Averill,D;Junck,L;Greenberg,HS
Since July 1985, 23 patients have been entered into a phase I/II clinical trial using intraarterial 5-bromodeoxyuridine (BUdR) (400–600 mg/m2daily for 8.5 weeks) and focal external beam radiotherapy (59.4 Gy at 1.8 Gy daily in 6.5 weeks) in the treatment of malignant gliomas (Kernohan grades 3 and 4). The side effects in all patients have included varying degrees of anorexia, fatigue, ipsilateral forehead dermatitis, blepharitis, and conjunctivitis. Mucopurulent conjunctivitis and exposure keratitis developed in several patients and spontaneous corneal perforation developed in one. Eyes from two individuals examined at autopsy showed significant changes. Animal studies that predated clinical trials using rhesus monkeys did not predict the ophthalmologic complications seen in human subjects.
