Avoiding Adverse Drug Withdrawal Events When Stopping Unnecessary Medications According to the STOPPFrail Criteria.
Avoiding Adverse Drug Withdrawal Events When Stopping Unnecessary Medications According to the STOPPFrail Criteria.
复制标题
根据停工标准，避免停止不必要的药物时避免不良药物提取事件。
DOI：
10.4140/tcp.n.2021.136
复制
发表时间：
2021-03-01
期刊：
影响因子：
--
通讯作者：
Tjia J
中科院分区：
文献类型：
--
作者：
Hanlon JT;Tjia J
为临床医生提供有关根据 STOPPFrail 标准停止不必要的药物时避免不良药物戒断事件 (ADWE) 的信息。 MEDLINE（1970 年至 2020 年 6 月）、Cochrane 系统评价数据库（截至 2020 年 6 月）、Google Scholar（截至 2020 年 6 月）的搜索。 ADWE 的评论和原创研究。来自随机对照减药试验的特定药物/类别的逐渐减少方案。六类药物被确定为生理性 ADWE 风险较高。与老年人的药物不良反应相比，ADWE 的发生很少见。据报道，很少有药物/类别会因突然停药而出现生理性 ADWE。对于这些，我们提供有关逐渐减少方案和症状监控的信息，以避免 ADWE。
To provide clinicians with information about avoiding adverse drug withdrawal events (ADWEs) when discontinuing unnecessary medications as per the STOPPFrail criteria. Searches of MEDLINE (1970-June 2020), the Cochrane Database of Systematic Reviews (through June 2020), Google Scholar (through June 2020). Reviews and original studies of ADWEs. Tapering protocols for specific drugs/ classes from randomized controlled deprescribing trials. Six drug classes were identified as being high risk for physiological ADWEs. The occurrence of ADWEs is rare in comparison to adverse drug reactions in older adults. Few drugs/classes have been reported to have physiological ADWEs with abrupt discontinuation. For these we provide information about tapering protocols and symptom monitoring to avoid ADWEs.