Hardness controlled enzymes and electronegativity controlled enzymes: role of an absolute hardness-electronegativity (eta-chi) activity diagram as a coordinate for biological activities.
Hardness controlled enzymes and electronegativity controlled enzymes: role of an absolute hardness-electronegativity (eta-chi) activity diagram as a coordinate for biological activities.
复制标题
硬度控制酶和电负性控制酶：绝对硬度-电负性 (eta-chi) 活性图作为生物活性坐标的作用。
DOI：
10.1248/cpb.46.1108
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发表时间：
1998
影响因子：
1.7
通讯作者：
Akira Tanaka
中科院分区：
文献类型：
--
作者：
Shigeki Kobayashi;Hajime Hamashima;Masaaki Kurihara;Naoki Miyata;Akira Tanaka
We found that absolute hardness-absolute electronegativity (eta-chi) activity diagrams play an important role as a new coordinate of bioactivity in structure-activity relationships. In this paper, the eta-chi activity diagram, focusing on the molecular mechanism of bioactive compounds is used to discuss two major problems. First, the potency of bioactivities for xenobiotics such as polychlorinated dibenzo-p-dioxins (PCDDs) 3 and polychlorinated biphenyls (PCBs) 4, were found to be strongly related to their absolute hardness (eta). Second, the antibacterial activity of new quinolones such as norfloxacin 1 and enoxacin 2, was found to be strongly related to their absolute electronegativity (chi). These findings predict at least two chemical properties for a hardness-controlled or electronegativity-controlled enzyme.
