PROSTAGLANDIN METABOLISM IN CHILDREN WITH DIABETES-MELLITUS .1. PLASMA PROSTAGLANDIN-E2, F2-ALPHA, TXB2, AND SERUM FATTY-ACID LEVELS
PROSTAGLANDIN METABOLISM IN CHILDREN WITH DIABETES-MELLITUS .1. PLASMA PROSTAGLANDIN-E2, F2-ALPHA, TXB2, AND SERUM FATTY-ACID LEVELS
复制标题
DOI：
10.1097/00005176-198611000-00009
复制
发表时间：
1986-11-01
影响因子：
2.9
通讯作者：
YAMASHIRO, Y
中科院分区：
文献类型：
--
作者：
ARISAKA, M;ARISAKA, O;YAMASHIRO, Y
目的研究胰岛素依赖型糖尿病儿童前列腺素（PG）代谢与血浆PGE2、pgf2 - α水平的关系。测定血栓素B2和血清脂肪酸组成。血小板聚集，糖尿病血管并发症的一个危险因素，也被测量。血浆PGE2和pgf2 - α的平均水平。高，血清二同γ -亚麻酸和花生四烯酸低。糖尿病患儿血浆血栓素B2水平与正常对照无显著差异。糖尿病患者的血小板聚集也增加。这些结果表明，糖尿病儿童的胰岛素缺乏和高血糖可能会干扰顺式亚油酸中二同γ -亚麻酸的供应，从而减少系列1中前列腺素的形成。然后反馈调节可增加PGE2和PGF2.alpha的产生。在系列2中。糖尿病儿童血管并发症的发生和发展可能与PG代谢的改变有关。
To study prostaglandin (PG) metabolism in children with insulin-dependent diabetes mellitus, plasma levels of PGE2, PGF2.alpha., and thromboxane B2 and the composition of serum fatty acids were measured. Platelet aggregation, a risk factor in diabetic vascular complications, was also measured. The mean levels of plasma PGE2 and PGF2.alpha. were high and serum dihomo-gamma-linolenic acid and arachidonic acid were low in the diabetic children. The plasma thromboxane B2 levels of the diabetic children and normal controls were not significantly different. Platelet aggregation was also increased in diabetic patients. These results suggest that the insulin deficiency and high blood sugar in diabetic children may disturb the supply of dihomo-gamma-linolenic acid from cis-linoleic acid, decreasing prostaglandin formation in series 1. Then feedback regulation may increase production of PGE2 and PGF2.alpha. in series 2. Altered PG metabolism may be responsible for the occurrence and progression of vascular complications in the diabetic children.