FACTORS AFFECTING PROGNOSIS IN EMPHYSEMA.
FACTORS AFFECTING PROGNOSIS IN EMPHYSEMA.
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影响肺气肿预后的因素。
DOI：
10.1378/chest.45.4.402
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
B. M. Lewis
中科院分区：
文献类型：
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作者：
S. F. Boushy;P. K. Adhikari;A. Sakamoto;B. M. Lewis
本文对61例肺气肿患者的预后进行了分析。20人死亡，幸存者平均随访36个月。在第一次就诊的临床结果中，只有肺心病和体重减轻在20名死亡患者中比在41名幸存者中更常见。在肺功能研究中，只有一氧化碳弥散量低（低于正常值的59%）和最大呼吸量低（低于正常值的30%）与预后不良有关。我们认为，最大呼吸量具有预后价值，因为它除了测量气道阻塞外，还测量了患者的力量和合作。弥散量具有预后价值，因为它反映了肺组织的破坏。在我们的数据中，弥散能力与肺心病的存在或发展无关，在那些死亡的人中弥散能力也不一定低。不均匀通风对弥散量测量的影响可以解释我们的工作与其他研究之间的矛盾。
Factors influencing prognosis in emphysema were investigated in 61 patients. Twenty died and the survivors were followed an average of 36 months. Of the clinical findings on the first visit, only cor pulmonale and weight loss were present significantly more often in the 20 patients who died than in the 41 survivors. Of the pulmonary function studies, only a low diffusing capacity for carbon monoxide (below 59 per cent of normal) and a low maximum breathing capacity (below 30 per cent of normal) were associated with a poor prognosis. The maximum breathing capacity, we feel, has prognostic value because it measures the patient's strength and cooperation in addition to airway obstruction. Diffusing capacity has prognostic value because it reflects destruction of pulmonary tissue. In our data, diffusing capacity is not related to the presence of or development of cor pulmonale, nor is it invariably low in those dying. The effect of uneven ventilation on the measurement of diffusing capacity may explain the conflict between our work and other studies on this relation.