Similarities between morphine withdrawal in the rat and the menopausal hot flush.
Similarities between morphine withdrawal in the rat and the menopausal hot flush.
复制标题
大鼠吗啡戒断与绝经期潮热之间的相似之处。
DOI：
10.1016/0024-3205(83)90047-4
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发表时间：
1983
期刊：
影响因子：
6.1
通讯作者：
Song,IC
中科院分区：
文献类型：
--
作者：
Simpkins,JW;Katovich,MJ;Song,IC
本研究通过观察大鼠吗啡戒断后的皮肤温度、心血管和神经内分泌反应，探讨建立绝经期潮热动物模型的可能性。吗啡依赖是由s.c.植入含有吗啡生物碱的药丸。作为对纳洛酮诱导的突然戒断的反应，大鼠表现出尾部皮肤温度（TST）的激增，其幅度（4.8至7.2°C）和持续时间（60至90分钟）相似到绝经期潮热期间报告的外周皮肤温度升高。此外，短暂的心率加快（59%）和9倍的促黄体生成素（LH）分泌过多之前，TST反应吗啡戒断。观察到这些心血管和神经内分泌反应先于或与绝经期潮热一致。此外，吗啡戒断后延长，导致TST不稳定的特点是自发的，高振幅的TST波动。因此，皮肤温度，心率和LH分泌的变化，在大鼠吗啡戒断过程中是类似的幅度，持续时间和时间关系，在潮热期间观察到的。这些数据表明，在这种血管功能障碍的可能阿片类药物的病因。吗啡成瘾大鼠急性戒断可作为研究更年期潮热神经机制的动物模型。
Skin temperature, cardiovascular and neuroendocrine responses to morphine withdrawal in the rat were evaluated in an effort to develop a potential animal model for the menopausal hot flush in women. Morphine dependency was produced by s.c. implantation of pellets containing morphine alkaloid. In response to precipitous, naloxone-induced withdrawal, rats showed surges in tail skin temperature (TST) which were similar in magnitude (4.8 to 7.2°C) and duration (60 to 90 min.) to peripheral skin temperature increases reported during menopausal hot flushes. Additionally, a brief period of accelerated heart rate (59 %) and a 9-fold hypersecretion of luteinizing hormone (LH) preceded the TST response to morphine withdrawal. These cardiovascular and neuroendocrine responses are observed to precede or coincide with the menopausal hot flush. Additionally, protracted morphine withdrawal subsequent to abstention, resulted in TST instability characterized by spontaneous, high amplitude TST fluctuations. Thus, the alteration in skin temperature, heart rate and LH secretion during precipitated morphine withdrawal in the rat are similar in magnitude, duration and in their temporal relationship to those observed during the hot flush. These data suggest a possible opioid etiology in this vasomotor disturbance. Acute withdrawal in the morphine addicted rats may serve as an animal model by which to study the neural mechanism underlying the menopausal hot flush.