Important roles of Akt/PKB signaling in the aging process.
Important roles of Akt/PKB signaling in the aging process.
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DOI：
10.2741/s125
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发表时间：
2010-06
期刊：
影响因子：
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通讯作者：
Miaozong Wu;Bin Wang;J. Fei;N. Santanam;E. Blough
中科院分区：
文献类型：
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作者：
Miaozong Wu;Bin Wang;J. Fei;N. Santanam;E. Blough
与不断增长的老年人口相关的成本增加预计将对卫生保健资源造成重大负担。从生物学角度来看，衰老是组织结构和功能的加速恶化过程，与较高的发病率和死亡率相关。Akt /蛋白激酶B（PKB）是丝氨酸/苏氨酸蛋白激酶家族，其在包括细胞存活、细胞生长、基因表达、细胞凋亡、蛋白质合成、能量代谢和肿瘤发生的多种过程中发挥重要作用。年龄相关的组织结构和功能变化可能与Akt表达和Akt依赖性信号传导的改变有关。在这里，我们回顾Akt可能在衰老过程中发挥的作用，并尝试在可能的情况下，强调这些数据如何可能导致新的调查方向和临床相关性的老年人。
The increased costs associated with an ever-growing aged population are expected to pose a significant burden on health care resources. From a biological standpoint, aging is an accelerated deteriorative process in tissue structure and function that is associated with higher morbidity and mortality. The Akt / protein kinase B (PKB) is a family of serine / threonine protein kinases, which play prominent roles in a diverse number of processes including cell survival, cell growth, gene expression, apoptosis, protein synthesis, energy metabolism and oncogenesis. It is likely that age-related changes in tissue structure and function are related to alterations in Akt expression and Akt-dependent signaling. Here we review the role that Akt may play in the aging process and attempt, where possible, to highlight how these data may lead to new directions of inquiry and clinical relevance to the aged.