CHARACTERIZATION OF STRESS-INDUCED LONG-TERM BEHAVIORAL-CHANGES IN RATS - EVIDENCE IN FAVOR OF ANXIETY
CHARACTERIZATION OF STRESS-INDUCED LONG-TERM BEHAVIORAL-CHANGES IN RATS - EVIDENCE IN FAVOR OF ANXIETY
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DOI：
10.1016/0031-9384(92)90375-c
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发表时间：
1992-11-01
影响因子：
2.9
通讯作者：
TILDERS, FJH
中科院分区：
文献类型：
--
作者：
VANDIJKEN, HH;MOS, J;TILDERS, FJH
最近，我们报道称，经历过短暂的不可避免的足部电击的老鼠表现出行为活动逐渐发展且持久的减少，以及在开阔场地排便的增加。本研究的目的是进一步表征对环境刺激的行为反应的长期变化。为此，使用了被验证为抑郁症心理生物学临床前研究工具的行为范式。在电击暴露后 14 天，与未电击的对照大鼠 (C) 相比，电击大鼠 (S) 在单向回避-逃避任务中表现出反应潜伏期缩短，在强迫游泳测试中表现出不动性降低。在足部电击暴露 28 天后进行的旷场测试中，与 C 大鼠相比，这些 S 大鼠表现出行为活动减少和排便增加。此外，足部电击暴露不会长期影响对 0.05% 糖精溶液的偏好或消耗，尽管 S 大鼠在电击后第 1 天明显减少了该溶液的消耗。与 C 大鼠相比，这些 S 大鼠在电击后第 11 天被置于新的环境中时，对背景噪音水平的突然降低表现出夸张的不动反应。我们的结论是，短暂的不可避免的足部电击的长期影响与动物抑郁症的行为表现并不相符。有人认为，休克引起的长期变化的共同点是行为防御性的增加，这更可能与恐惧和/或焦虑的增加有关。
Recently, we reported that rats exposed to one brief session of inescapable footshocks showed a gradually developing and long-lasting decrease in behavioural activity and an increase in defecation in an open field. The aim of the present study was to further characterize the long-lasting changes in behavioural responsiveness to environmental stimuli. For this purpose, behavioural paradigms validated as tools in the preclinical study of the psychobiology of depression were used. Footshocked rats (S) showed a decreased response latency in an one-way avoidance-escape task and decreased immobility in a forced swim test as compared to nonshocked control rats (C) 14 days after shock exposure. These S rats showed decreased behavioural activity and increased defecation as compared to the C rats in an open field test carried out 28 days after footshock exposure. In addition, footshock exposure did not affect the preference for or consumption of a 0.05% saccharin solution on a long-term basis, although a decreased consumption of this solution was evident in S rats on day 1 postshock. These S rats showed an exaggerated immobility response to a sudden reduction in background noise level compared to C rats while placed in a novel environment on day 11 postshock. We conclude that the long-term effects of one short session of inescapable footshocks are not compatible with what is supposed to represent behavioural manifestations of depression in animals. It is argued that the common denominator of shock-induced long-lasting changes is increased behavioural defensiveness, which is more likely related to increased fear and/or anxiety.