IMMUNE ACTIVATION IN MULTIPLE-SCLEROSIS - STUDY OF IL-2, SIL-2R, AND GAMMA-IFN LEVELS IN SERUM AND CEREBROSPINAL-FLUID
IMMUNE ACTIVATION IN MULTIPLE-SCLEROSIS - STUDY OF IL-2, SIL-2R, AND GAMMA-IFN LEVELS IN SERUM AND CEREBROSPINAL-FLUID
复制标题
DOI：
10.1016/0022-510x(89)90171-8
复制
发表时间：
1989-08-01
影响因子：
4.4
通讯作者：
TAVOLATO, B
中科院分区：
文献类型：
--
作者：
GALLO, P;PICCINNO, MG;TAVOLATO, B
白细胞介素-2（IL-2）、可溶性IL-2受体（sIL-2 R）和γ-干扰素（γ-IFN）的血清和脑脊液（CSF）水平测定了多发性硬化（MS）患者、人类免疫缺陷病毒1型（HIV-1）感染者和正常对照（NC）的血清IFN-γ水平。MS患者血清IL-2和sIL-2 R水平升高。此外，50例MS患者中有11例在CSF中显示出可检测水平的IL-2。HIV-1感染患者血清中sIL-2 R水平升高，CSF中sIL-2 R水平升高较少。γ-所有患者的血清和CSF中均未检测到IFN。这些发现证实了初步报告，进一步强调了MS中的系统性T细胞活化，并支持了这类患者中存在免疫紊乱的假设。
Serum and cerebrospinal fluid (CSF) levels of interleukin-2 (IL-2), soluble IL-2 receptor (sIL-2R), and gamma-interferon (.gamma.-IFN) were measured in multiple sclerosis (MS) patients, human immunodeficiency virus type 1 (HIV-1)-infected patients and normal controls (NC). Increased levels of both IL-2 and sIL-2R were found in MS serum. Moreover, 11 of 50 MS patients showed detectable levels of IL-2 in the CSF. HIV-1-infected patients had increased levels of sIL-2R in serum and, less frequently, in the CSF. .gamma.-IFN was never detected in serum and CSF of all the patients studied. These findings confirm preliminary reports, further stress a systemic T-cell activation in MS, and support the hypothesis that an immunologic disorder exists in such patients.