Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway
Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway
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Lycorine 通过诱导细胞凋亡和阻断 Src/FAK 相关途径抑制乳腺癌生长和转移
DOI：
10.1007/s11427-016-0368-y
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发表时间：
2017-04-01
影响因子：
9.1
通讯作者：
He, Pingqing
中科院分区：
文献类型：
--
作者：
Ying, Xuexiang;Huang, Anling;He, Pingqing
乳腺癌是全世界女性中最常见的癌症类型，90%以上的患者死于肿瘤转移。石蒜碱是一种天然生物碱，被广泛报道具有潜在的抗肿瘤增殖和转移作用。在本研究中，我们首次在体外评价了vitroandin对乳腺癌的抗肿瘤作用。结果表明，石蒜碱能抑制乳腺癌细胞的生长、迁移和侵袭，并诱导其凋亡。在体内研究中，石蒜碱不仅能抑制异种移植瘤模型中乳腺肿瘤的生长，还能抑制MDA-MB-231尾静脉模型中乳腺肿瘤的转移。更重要的是，我们发现在体内相同有效剂量下，石蒜碱的毒性低于一线化疗药物紫杉醇。此外，在机制上，石蒜碱通过阻断Src/FAK（局灶黏附激酶）参与的途径抑制肿瘤细胞的迁移和侵袭。总之，我们的研究表明，石蒜碱是一种潜在的候选药物，可以通过抑制肿瘤的生长和转移来治疗乳腺癌。
Breast cancer is the most commonly diagnosed cancer type worldwide among women and more than 90% of patients die from tumor metastasis. Lycorine, a natural alkaloid, has been widely reported possessing potential efficacy against cancer proliferation and metastasis. In our study, the anti-tumor potency on breast cancer was evaluatedin vitroandin vivofor the first time. Our results indicated that lycorine inhibited breast cancer cells growth, migration and invasion as well as induced their apoptosis. Inin vivostudy, lycorine not only suppressed breast tumor growth in xenograft models and inhibited breast tumor metastasis in MDA-MB-231 tail vein model. More importantly, we found lycorine had less toxicity than first-line chemotherapy drug paclitaxel at the same effective dosein vivo. Furthermore, on mechanism, lycorine inhibited tumor cell migration and invasion via blocking the Src/FAK (focal adhesion kinase)-involved pathway. In conclusion, our study implied lycorine was a potential candidate for the treatment of breast cancer by inhibition of tumor growth and metastasis.