Larger volume and different functional connectivity of the amygdala in women with premenstrual syndrome
Larger volume and different functional connectivity of the amygdala in women with premenstrual syndrome
复制标题
经前综合症女性杏仁核体积较大且功能连接不同
DOI：
10.1007/s00330-017-5206-0
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发表时间：
2018-05-01
影响因子：
5.9
通讯作者：
Li, Min
中科院分区：
文献类型：
--
作者：
Deng, Demao;Pang, Yong;Li, Min
目的应用磁共振成像（MRI）技术评价经前期综合征（PMS）对杏仁核结构和功能的影响。方法20例经前综合征患者和21例健康对照（HC）在黄体期进行6 min静息状态fMRI扫描，并扫描高分辨率t1加权图像。评估两组之间皮质下杏仁核相关体积和功能连通性（FC）。每位受试者完成每日问题严重程度记录（DRSP），以衡量临床症状的严重程度。结果PMS患者双侧杏仁核体积大于HC组，杏仁核与额叶皮层部分区域（内侧前额叶皮层、前扣带皮层、右侧中央前回）、右侧颞极和脑岛之间的FC增加，双侧杏仁核与右侧眶额叶皮层和右侧海马之间的FC减少。PMS患者右侧杏仁核与右侧中央前回、左侧ACC和左侧mPFC之间的FC强度与DRSP评分呈显著正相关。结论我们的发现有助于进一步了解经前症候群的神经机制。•功能和结构MRI用于探索经前症候群患者的杏仁核。•在经前症候群患者中发现异常的杏仁核结构和功能连接。•杏仁核强度FC与个体临床症状评分呈正相关。
ObjectivesTo assess structural and functional changes of the amygdala due to premenstrual syndrome (PMS) using magnetic resonance imaging (MRI).MethodsTwenty PMS patients and 21 healthy control (HC) subjects underwent a 6-min resting-state fMRI scan during the luteal phase as well as scanning high-resolution T1-weighted images. Subcortical amygdala-related volume and functional connectivity (FC) were estimated between the two groups. Each subject completed a daily record of severity of problems (DRSP) to measure the severity of clinical symptoms.ResultsGreater bilateral amygdalae volumes were found in PMS patients compared with HC subjects, and PMS patients had increased FC between the amygdala and certain regions of the frontal cortex (e.g. medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), right precentral gyrus), the right temporal pole and the insula, as well as decreased FC between the bilateral amygdalae and the right orbitofrontal cortex and right hippocampus. The strength of FC between the right amygdala and right precentral gyrus, left ACC and left mPFC were significantly and positively correlated with DRSP scores in PMS patients.ConclusionsOur findings may improve our understanding of the neural mechanisms involved in PMS.Key Points•Functional and structural MRI used to explore amygdala in PMS patients.•Aberrant amygdala structural and functional connectivity were found in PMS patients.•Amygdala strength FC was positively correlated with individual clinical symptom scores.