Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: empirical data and simulations
Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: empirical data and simulations
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DOI：
10.1016/s0006-8993(99)02248-9
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发表时间：
2000-02-28
期刊：
影响因子：
2.9
通讯作者：
Tobler, I
中科院分区：
文献类型：
--
作者：
Huber, R;Deboer, T;Tobler, I
基因靶向小鼠可以作为研究睡眠调节机制的模型。三种常用的基因靶向背景菌株（129/OIa）。129/SvJ和C57BL/6J)分别进行4 h和6 h睡眠剥夺（SD），连续记录睡眠和睡眠脑电图。睡眠调节的双过程模型预测了人类和大鼠在多次睡眠-觉醒操作后非快速眼动睡眠中慢波活动（SWA）的时间过程[3,9]。我们测试了该模型在小鼠睡眠时间组织的基础上预测非快速眼动睡眠中SWA的能力。各毒株在睡眠时间、睡眠分布和SWA时间过程上存在差异。自发性醒后10-30分钟以及SD后，SWA不变地增加。129/SvJ和C57BL/6J的SWA时间过程模拟成功，但129/OIa的SWA时间过程模拟不理想。由于时间常数被认为反映了参与睡眠调节的生理过程的动态，因此该结果为使用基因靶向小鼠研究其潜在机制提供了基础。(C) 2000 Elsevier Science B.V.版权所有
Gene targeted mice can be used as models to investigate the mechanisms underlying sleep regulation. Three commonly used background strains fur gene targeting (129/OIa. 129/SvJ and C57BL/6J) were subjected to 4-h and 6-h sleep deprivation (SD)I and their sleep and sleep EEG were continuously recorded. The two-process model of sleep regulation ha predicted the time course of slow-wave activity (SWA) in nonREM sleep after several sleep-wake manipulations in humans and the rat [3,9]. We tested the capacity of the model to predict SWA in nonREM sleep on the basis of the temporal organization of sleep in mice. The strains differed in the amount and distribution of sleep and the time course of SWA. After spontaneous waking episodes of 10-30 min as well as after SD, SWA was invariably increased. Simulations of the time course of SWA were successful for 129/SvJ and C57BL/6J bur were not satisfactory for 129/OIa. Since the time constants are assumed to reflect the dynamics of the physiological processes involved in sleep regulation, the results provide a basis for the use of gene targeted mice to investigate the underlying mechanisms. (C) 2000 Elsevier Science B.V. All rights reserved.