Drusen in the Peripheral Retina of the Alzheimer's Eye
Drusen in the Peripheral Retina of the Alzheimer's Eye
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DOI：
10.2174/1567205015666180123122637
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发表时间：
2018-01-01
影响因子：
2.1
通讯作者：
Matsubara, Joanne A.
中科院分区：
文献类型：
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作者：
Ukalovic, Kresimir;Cao, Sijia;Matsubara, Joanne A.
背景：最近关于阿尔茨海默病(AD)诊断的工作主要集中在神经成像方法上；然而，这些方法昂贵，具有侵入性，并不是所有患者都可以使用。生物标志物的眼部成像，如周围视网膜中的玻璃体，可以为诊断AD提供一种替代方法。目的：本研究比较了对照组和AD眼的黄斑和周围玻璃体负荷。对来自正常捐赠者的视网膜进行处理，并将其归类为更年轻的(=55岁)组。在固定和解剖后，在黄斑区和周边(颞区、上区和下区)视网膜进行3~6 mm的RPE/脉络膜穿刺术。油红O阳性红斑计数分为两大类：小号(
Background: Recent work on Alzheimer's disease (AD) diagnosis focuses on neuroimaging modalities; however, these methods are expensive, invasive, and not available to all patients. Ocular imaging of biomarkers, such as drusen in the peripheral retina, could provide an alternative method to diagnose AD.Objective: This study compares macular and peripheral drusen load in control and AD eyes.Methods: Postmortem eye tissues were obtained from donors with a neuropathological diagnosis of AD. Retina from normal donors were processed and categorized into younger (= 55 years) groups. After fixation and dissection, 3-6 mm punches of RPE/choroid were taken in macular and peripheral (temporal, superior, and inferior) retinal regions. Oil red O positive drusen were counted and grouped into two size categories: small (