Regulator of G Protein Signaling-4 Controls Fatty Acid and Glucose Homeostasis
Regulator of G Protein Signaling-4 Controls Fatty Acid and Glucose Homeostasis
复制标题
DOI：
10.1210/en.2008-0717
复制
发表时间：
2008-11-01
期刊：
影响因子：
4.8
通讯作者：
Fajas, Lluis
中科院分区：
文献类型：
--
作者：
Iankova, Irena;Chavey, Carine;Fajas, Lluis
循环游离脂肪酸是脂肪生成和脂解之间平衡的反映，主要发生在脂肪组织中。我们发现，G蛋白信号调节因子（RGS）-4缺乏的小鼠循环中的儿茶酚胺增加，游离脂肪酸增加。因此，RGS 4（-/-）小鼠具有增加的循环游离脂肪酸浓度;在肝脏中异常积累脂肪酸，导致肝脏脂肪变性;并且显示更高程度的葡萄糖耐受不良和胰腺中胰岛素分泌减少。我们在这项研究中表明，RGS 4通过调节肾上腺分泌的儿茶酚胺来控制脂肪组织脂解。RGS 4控制脂肪组织脂解和脂肪生成之间的平衡，其次是其在肾上腺调节儿茶酚胺分泌中的作用。因此，RGS 4可能是治疗代谢性疾病的良好靶标。（内分泌学149：5706-5712，2008）
Circulating free fatty acids are a reflection of the balance between lipogenesis and lipolysis that takes place mainly in adipose tissue. We found that mice deficient for regulator of G protein signaling (RGS)-4 have increased circulating catecholamines, and increased free fatty acids. Consequently, RGS4(-/-) mice have increased concentration of circulating free fatty acids; abnormally accumulate fatty acids in liver, resulting in liver steatosis; and show a higher degree of glucose intolerance and decreased insulin secretion in pancreas. We show in this study that RGS4 controls adipose tissue lipolysis through regulation of the secretion of catecholamines by adrenal glands. RGS4 controls the balance between adipose tissue lipolysis and lipogenesis, secondary to its role in the regulation of catecholamine secretion by adrenal glands. RGS4 therefore could be a good target for the treatment of metabolic diseases. (Endocrinology 149: 5706-5712, 2008)