Working Overtime: Altered Functional Connectivity in Working Memory Following Regular Cannabis Use in Young Adults
Working Overtime: Altered Functional Connectivity in Working Memory Following Regular Cannabis Use in Young Adults
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DOI：
10.1007/s11469-020-00226-y
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发表时间：
2020-01-29
影响因子：
8
通讯作者：
Smith, Andra
中科院分区：
文献类型：
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作者：
Hatchard, Taylor;Byron-Alhassan, Aziza;Smith, Andra
越来越多的人认为，经常使用大麻可能对发育中的大脑有害，包括对执行功能的潜在长期改变。因此，本研究利用功能性磁共振成像（fMRI）对来自纵向研究样本的年轻人（19至21岁）进行了工作记忆n-back任务的神经激活和表现检测。在fMRI期间完成字母n-back任务时，将常规大麻使用者（n = 10）与非常规大麻使用者对照（n = 14）进行比较。虽然表现指标之间没有差异，但成像参数显示在任务执行过程中大脑活动存在显著差异。具体来说，有证据表明，大麻使用者的左右颞叶和右上额叶皮层的激活增加，包括这些区域之间的功能连接显著改变。功能连接分析还显示，大麻使用者的工作记忆和奖励回路的预期连接模式存在差异，这可能反映了持续使用大麻的补偿机制。
There is an emerging consensus that regular cannabis use may be detrimental to the developing brain, including potential long-lasting changes in executive functioning. Consequently, the present study examined neural activation and performance on a working memory n-back task using functional magnetic resonance imaging (fMRI) in a sample of young adults (ages 19 to 21) from a longitudinal research sample. Regular cannabis users (n = 10) were compared with non-regular cannabis user controls (n = 14) while completing the letter n-back task during fMRI. While there were no differences across performance indices, imaging parameters showed significant differences in brain activation during task performance. Specifically, there was evidence of increased activation in the left and right temporal lobes and the right superior frontal cortex in cannabis users, including significantly altered functional connectivity between these areas. Functional connectivity analyses also showed differences in expected patterns of connectivity in both working memory and reward circuitries among cannabis users, possibly reflecting compensatory mechanisms as a result of sustained use.