Plasticity-dependent changes in metabotropic glutamate receptor expression at excitatory hippocampal synapses
Plasticity-dependent changes in metabotropic glutamate receptor expression at excitatory hippocampal synapses
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DOI：
10.1016/j.mcn.2007.10.015
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发表时间：
2008-03-01
影响因子：
3.5
通讯作者：
Montgomery, Johanna M.
中科院分区：
文献类型：
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作者：
Cheyne, Juliette E.;Montgomery, Johanna M.
I组代谢型谷氨酸受体mGluR1和mGluR5调节NMDA受体介导的突触传递和可塑性，并介导mGluR依赖性可塑性。在这里，我们报告的mGluRs的突触表达可以调节NMDA受体依赖性突触可塑性，但这是依赖于亚型的mGluR。发现沉默突触而不是活跃突触缺乏I组mGluR，这表明mGluR必须在它们不沉默后插入突触中。LTP的诱导以NMDA受体依赖的方式导致mGluR1的突触表达增加。mGluR1通过NMDA受体依赖性LTD从突触内化。有趣的是，我们没有发现NMDA受体依赖性可塑性调节mGluR5的证据。I组mGluR的这种调节将决定突触对突触传递和可塑性进行mGluR依赖性调节的能力，为海马突触的元可塑性和状态依赖性可塑性提供机制。(c)2007年爱思唯尔公司All rights reserved.
Group I metabotropic glutamate receptors, mGluR1 and mGluR5, modulate NMDA receptor-mediated synaptic transmission and plasticity and mediate mGluR-dependent plasticity. Here we report that the synaptic expression of mGluRs can be regulated by NMDA receptor-dependent synaptic plasticity, but that this is dependent on the subtype of mGluR. Silent synapses, but not active synapses, were found to lack Group I mGluRs showing that mGluRs must be inserted into synapses after they are unsilenced. The induction of LTP resulted in an increased synaptic expression of mGluR1 in an NMDA receptor-dependent manner. mGluR1 is internalized from synapses via NMDA receptor-dependent LTD. Interestingly we found no evidence for the regulation of mGluR5 by NMDA receptor-dependent plasticity. This regulation of Group I mGluRs will determine the ability of synapses to undergo mGluR-dependent modulation of synaptic transmission and plasticity, providing a mechanism for metaplasticity and state-dependent plasticity at hippocampal synapses. (c) 2007 Elsevier Inc. All rights reserved.