Deep-inspiration breath-hold PET/CT of lung cancer: Maximum standardized uptake value analysis of 108 patients
Deep-inspiration breath-hold PET/CT of lung cancer: Maximum standardized uptake value analysis of 108 patients
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DOI：
10.2967/jnumed.107.049296
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发表时间：
2008-08-01
影响因子：
9.3
通讯作者：
Inoue, Tornio
中科院分区：
文献类型：
--
作者：
Kawano, Tsuyoshi;Ohtake, Eiji;Inoue, Tornio
我们的目的是比较屏气(BH)PET/CT和自由呼吸(FB)PET/CT的最大标准摄取值(SUVmax)。方法：分析体模数据的特点，并进行临床研究。对108例肺癌患者进行了基于氧硅酸(LSO)的PET/CT检查。在FBPET/CT检查中指导患者自由呼吸。BH型正电子发射计算机断层扫描(BHPET/CT)要求患者在扫查时屏气至最大吸气位，连续屏气10 S，并在正电子发射计算机断层扫描中尽可能长时间屏气。用呼吸监测装置记录BH时间。%BH指数定义为FBPET的SUVmax与BHPET的SUVmax之差的百分比。统计分析使用以下因素：%BH指数、年龄、体重指数、F-18-FDG剂量、血糖、BH时间、病变大小和位置。结果：最高的%BH指数为223.2。下肺区的%BH指数显著高于上肺区(分别为51.8±49.5和16.9±25.6)。高%BH指数组的病变体积和最大直径显著低于低%BH指数组，%BH指数截断值为37.1。结论：FBPET的SUVmax不应被认为是准确的，尤其是在下肺区和肺部微小病变。BH PET/CT有望实现SUVmax的精确测量，因此建议将其作为肺癌标准方案的一部分。
Our aim was to compare the maximum standardized uptake value (SUVmax) between breath-hold (BH) PET/CT and free-breathing (FB) PET/CT. Methods: The features of phantom data were analyzed, after which a clinical study was performed. A total of 108 consecutive patients with lung cancer were examined using lutetium oxyorthosilicate (LSO)-based PET/CT. The patients were instructed to breathe freely during FB PET/CT. In BH PET/CT, the patients were instructed to hold their breath in the maximal inspiration position during the scout scan, for 10 s of the CT scan, and for as long as possible during the PET scan. BH time was recorded using a respiratory monitoring device. The %BH-index was defined as the percentage difference between SUVmax of FB PET and that of BH PET. Statistical analyses were performed using the following factors: %BH-index, age, body mass index, F-18-FDG dosage, blood glucose, BH time, lesion size, and location. Results: The highest %BH-index was 223.2. %BH-index in the lower lung area was significantly higher than that in the upper lung area (51.8 +/- 49.5 vs. 16.9 +/- 25.6, respectively). Lesion volume and maximum diameter in the high-%BH-index group were significantly lower than those in the low-%BH-index group, with the use of a %BH-index cutoff value of 37.1. Conclusion: SUVmax of FB PET should not be taken as accurate, especially in the lower lung area and for small pulmonary lesions. BH PET/CT is expected to enable precise measurement of SUVmax: and is thus recommended as part of the standard protocol for lung cancer.