Application of next-generation sequencing in clinical oncology to advance personalized treatment of cancer.
Application of next-generation sequencing in clinical oncology to advance personalized treatment of cancer.
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DOI：
10.5732/cjc.012.10216
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发表时间：
2012-10
影响因子：
--
通讯作者：
Peng Y
中科院分区：
文献类型：
--
作者：
Guan YF;Li GR;Wang RJ;Yi YT;Yang L;Jiang D;Zhang XP;Peng Y
随着新测序技术的发展和完善，下一代测序技术在肿瘤基因组学研究中的应用日益广泛。最近，NGS已被用于临床肿瘤学，以推进癌症的个性化治疗。NGS用于识别新的和罕见的癌症突变，检测家族性癌症突变携带者，并为适当的靶向治疗提供分子基础。与传统测序相比，NGS具有许多优势，例如能够以相对较低的成本在单次测试中对大量基因（数百至数千个）的所有类型的突变进行完全测序。然而，必须克服重大挑战，特别是关于对更简单的测定、更灵活的通量、更短的周转时间以及最重要的是更容易的数据分析和解释的要求，以将NGS转化为癌症患者的床边。总体而言，持续致力于在临床肿瘤学实践中应用NGS将使我们更接近个性化医疗。
With the development and improvement of new sequencing technology, next-generation sequencing (NGS) has been applied increasingly in cancer genomics research over the past decade. More recently, NGS has been adopted in clinical oncology to advance personalized treatment of cancer. NGS is used to identify novel and rare cancer mutations, detect familial cancer mutation carriers, and provide molecular rationale for appropriate targeted therapy. Compared to traditional sequencing, NGS holds many advantages, such as the ability to fully sequence all types of mutations for a large number of genes (hundreds to thousands) in a single test at a relatively low cost. However, significant challenges, particularly with respect to the requirement for simpler assays, more flexible throughput, shorter turnaround time, and most importantly, easier data analysis and interpretation, will have to be overcome to translate NGS to the bedside of cancer patients. Overall, continuous dedication to apply NGS in clinical oncology practice will enable us to be one step closer to personalized medicine.
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影响因子：
64.8
作者：
Ellis, Matthew J.;Ding, Li;Shen, Dong;Luo, Jingqin;Suman, Vera J.;Wallis, John W.;Van Tine, Brian A.;Hoog, Jeremy;Goiffon, Reece J.;Goldstein, Theodore C.;Ng, Sam;Lin, Li;Crowder, Robert;Snider, Jacqueline;Ballman, Karla;Weber, Jason;Chen, Ken;Koboldt, Daniel C.;Kandoth, Cyriac;Schierding, William S.;McMichael, Joshua F.;Miller, Christopher A.;Lu, Charles;Harris, Christopher C.;McLellan, Michael D.;Wendl, Michael C.;DeSchryver, Katherine;Allred, D. Craig;Esserman, Laura;Unzeitig, Gary;Margenthaler, Julie;Babiera, G. V.;Marcom, P. Kelly;Guenther, J. M.;Leitch, Marilyn;Hunt, Kelly;Olson, John;Tao, Yu;Maher, Christopher A.;Fulton, Lucinda L.;Fulton, Robert S.;Harrison, Michelle;Oberkfell, Ben;Du, Feiyu;Demeter, Ryan;Vickery, Tammi L.;Elhammali, Adnan;Piwnica-Worms, Helen;McDonald, Sandra;Watson, Mark;Dooling, David J.;Ota, David;Chang, Li-Wei;Bose, Ron;Ley, Timothy J.;Piwnica-Worms, David;Stuart, Joshua M.;Wilson, Richard K.;Mardis, Elaine R.
通讯作者：
Mardis, Elaine R.
三七根转录组分析揭示了假定的三萜皂苷生物合成基因和遗传标记
影响因子：
4.4
作者：
Luo H;Sun C;Sun Y;Wu Q;Li Y;Song J;Niu Y;Cheng X;Xu H;Li C;Liu J;Steinmetz A;Chen S
通讯作者：
Chen S
影响因子：
3.7
作者：
Keller A;Harz C;Matzas M;Meder B;Katus HA;Ludwig N;Fischer U;Meese E
通讯作者：
Meese E
影响因子：
64.8
作者：
Berger, Michael F.;Lawrence, Michael S.;Demichelis, Francesca;Drier, Yotam;Cibulskis, Kristian;Sivachenko, Andrey Y.;Sboner, Andrea;Esgueva, Raquel;Pflueger, Dorothee;Sougnez, Carrie;Onofrio, Robert;Carter, Scott L.;Park, Kyung;Habegger, Lukas;Ambrogio, Lauren;Fennell, Timothy;Parkin, Melissa;Saksena, Gordon;Voet, Douglas;Ramos, Alex H.;Pugh, Trevor J.;Wilkinson, Jane;Fisher, Sheila;Winckler, Wendy;Mahan, Scott;Ardlie, Kristin;Baldwin, Jennifer;Simons, Jonathan W.;Kitabayashi, Naoki;MacDonald, Theresa Y.;Kantoff, Philip W.;Chin, Lynda;Gabriel, Stacey B.;Gerstein, Mark B.;Golub, Todd R.;Meyerson, Matthew;Tewari, Ashutosh;Lander, Eric S.;Getz, Gad;Rubin, Mark A.;Garraway, Levi A.
通讯作者：
Garraway, Levi A.
影响因子：
3.9
作者：
De Leeneer, Kim;Hellemans, Jan;Claes, Kathleen
通讯作者：
Claes, Kathleen