Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women.
Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women.
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DOI：
10.1210/js.2017-00020
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发表时间：
2017-06-01
影响因子：
4.1
通讯作者：
Dannenberg AJ
中科院分区：
文献类型：
--
作者：
Alemán JO;Iyengar NM;Walker JM;Milne GL;Da Rosa JC;Liang Y;Giri DD;Zhou XK;Pollak MN;Hudis CA;Breslow JL;Holt PR;Dannenberg AJ
肥胖与亚临床白色脂肪组织炎症有关，其定义为冠状结构(CLSS)的存在，该结构由死亡或死亡的脂肪细胞被巨噬细胞包围。在人类中，减肥手术导致的体重下降会导致CLSS的减少，但快速饮食诱导的体重减轻对CLSS和新陈代谢的影响尚不清楚。目的：确定极低热量饮食诱导的快速减肥对肥胖绝经后妇女CLS密度、全身炎症生物标志物和代谢的影响。前瞻性队列研究。洛克菲勒大学医院，纽约州。10名肥胖的绝经后妇女，平均年龄为60.6岁(标准差，±3.6岁)。检测对腹部皮下脂肪组织CLS密度和基因表达、心脏代谢危险因素、白细胞计数、循环代谢产物和氧化应激(尿异前列腺素-M)的影响。肥胖受试者平均在46天内减掉了大约10%的体重。皮下脂肪组织中CLS密度增加，而致炎基因表达没有相关增加。伴随着体重减轻的是，空腹血中高敏C反应蛋白、葡萄糖、乳酸和犬尿氨酸水平下降，循环中游离脂肪酸、甘油、β-羟丁酸酯和25羟基维生素D水平上升。尿异前列腺素-M水平下降。快速减肥刺激脂肪分解和皮下脂肪组织中CLS密度的增加，与循环代谢物水平的变化有关，并改善了全身炎症和胰岛素抵抗的生物标志物。观察到的代谢物(即乳酸、β-羟基丁酸酯、25-羟基维生素D)水平的变化可能有助于快速减肥的抗炎效果。饮食诱导的快速减肥增加了肥胖绝经后女性的皮下脂肪冠状结构密度。
Obesity is associated with subclinical white adipose tissue inflammation, as defined by the presence of crown-like structures (CLSs) consisting of dead or dying adipocytes encircled by macrophages. In humans, bariatric surgery-induced weight loss leads to a decrease in CLSs, but the effects of rapid diet-induced weight loss on CLSs and metabolism are unclear. To determine the effects of rapid very-low-calorie diet-induced weight loss on CLS density, systemic biomarkers of inflammation, and metabolism in obese postmenopausal women. Prospective cohort study. Rockefeller University Hospital, New York, NY. Ten obese, postmenopausal women with a mean age of 60.6 years (standard deviation, ±3.6 years). Effects on CLS density and gene expression in abdominal subcutaneous adipose tissue, cardiometabolic risk factors, white blood count, circulating metabolites, and oxidative stress (urinary isoprostane-M) were measured. Obese subjects lost approximately 10% body weight over a mean of 46 days. CLS density increased in subcutaneous adipose tissue without an associated increase in proinflammatory gene expression. Weight loss was accompanied by decreased fasting blood levels of high-sensitivity C-reactive protein, glucose, lactate, and kynurenine, and increased circulating levels of free fatty acids, glycerol, β-hydroxybutyrate, and 25 hydroxyvitamin D. Levels of urinary isoprostane-M declined. Rapid weight loss stimulated lipolysis and an increase in CLS density in subcutaneous adipose tissue in association with changes in levels of circulating metabolites, and improved systemic biomarkers of inflammation and insulin resistance. The observed change in levels of metabolites (i.e., lactate, β-hydroxybutyrate, 25 hydroxyvitamin D) may contribute to the anti-inflammatory effect of rapid weight loss. Rapid diet-induced weight loss increases subcutaneous adipose crown-like structure density in obese postmenopausal women.