Changes in Molecular Characteristics of Mycoplasma pneumoniae in Clinical Specimens from Children in Beijing between 2003 and 2015.
Changes in Molecular Characteristics of Mycoplasma pneumoniae in Clinical Specimens from Children in Beijing between 2003 and 2015.
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2003-2015年北京市儿童临床标本肺炎支原体分子特征变化
DOI：
10.1371/journal.pone.0170253
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Sun H;Xue G;Yan C;Li S;Zhao H;Feng Y;Wang L
分析了2003年至2015年期间从中国北京儿童患者中收集的480份肺炎支原体聚合酶链反应阳性标本（331份为既往报告，149份为新报告）的分子特征。基因型M4-5-7-2/P1在13年的研究期间最普遍，尽管该基因型的分离和突变率在2003-2007年，2008-2013年和2014-2015年期间有所不同。此外，M4-5-7-2基因型与大环内酯类药物耐药密切相关。
The molecular characteristics of 480 Mycoplasma pneumoniae polymerase chain reaction-positive specimens (331 were previously reported and 149 were newly reported) collected from pediatric patients in Beijing, China, between 2003 and 2015 were analyzed. Genotype M4-5-7-2/P1 were the most prevalent across the 13-year study period, although the isolation and mutation rates for this genotype varied between the periods 2003–2007, 2008–2013, and 2014–2015. In addition, there was a close association between the M4-5-7-2 genotype and macrolide resistance.