Natural Infection of Man with Group A Streptococci
Natural Infection of Man with Group A Streptococci
复制标题
人类 A 族链球菌的自然感染
DOI：
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发表时间：
1976
影响因子：
3.7
通讯作者：
D. Braun
中科院分区：
文献类型：
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作者：
W. Riesen;F. Skvaril;D. Braun
通过改良的Farr技术研究了人血清中A组和A组变异链球菌两种血清学不同多糖的特异性抗体水平。尽管抗链球菌溶血素O滴度与A组特异性抗体水平之间存在明显相关性，表明近期A组链球菌感染，但A组变体抗体水平的相关性不明显。有证据表明，儿童的A组多糖抗体水平显著低于成人;这不是他们的A组变异抗体水平。A组和A变体特异性抗体明显局限于κ轻链类型和IgG 2重链亚类。尽管只有1份血清含有也与IgG 3重链相关的A组特异性抗体，但9份血清含有同时具有IgG 2和IgG 3重链的抗A组变体特异性抗体。在IgM和伊加类血清抗体中未检测到抗多糖活性。人血清的抗A型和抗A型变体抗体在等电聚焦显示的克隆型数量方面受到限制。最异质的血清含有大约10个克隆型。
The level of antibodies specific for the two serologically distinct polysaccharides of group A and group A‐variant streptococci was investigated in human sera by a modified Farr technique. Whereas there was an obvious relationship between the anti‐streptolysin O titer and the level of group‐A‐specific antibodies, suggesting a recent streptococcal infection with group A streptococci, this correlation was not apparent for the level of group A‐variant antibodies. There is evidence suggesting that children have significantly lower group A polysaccharide antibody levels than adults; this is not true of their group A‐variant antibody levels. There was an apparent restriction of groups A‐ and A‐variant‐specific antibodies to the κ light‐chain type and IgG2 heavy‐chain subclass. Whereas only one serum contained group A‐specific antibodies also associated with IgG3 heavy chains, nine sera contained anti‐group A‐variant‐specific antibodies with both IgG2 and IgG3 heavy chains. No anti‐polysaccharide activity was detected in the IgM and IgA class of serum antibodies. Anti‐group A and anti‐group A‐variant antibodies of human sera are restricted with respect to the number of clonotypes that are shown by isoelectric focusing. The most heterogeneous sera contained roughly ten clonotypes.