Neurogenesis, Myelination, and Circuitry: The Case for a Distributed Therapeutic Regimen in Down Syndrome.

Neurogenesis, Myelination, and Circuitry: The Case for a Distributed Therapeutic Regimen in Down Syndrome.
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DOI:
10.1352/1944-7558-125.2.100
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发表时间:
2020-03
期刊:
American journal on intellectual and developmental disabilities
影响因子:
--
通讯作者:
Haydar TF
Haydar TF
中科院分区:
其他
文献类型:
--
作者:
Haydar TF

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唐氏综合症(DS)研究界压倒一切的希望之一是更好地了解21三体如何影响大脑发育和功能,并认为这样做将提高DS患者的生活质量和独立性。在寻找DS智能障碍的根本原因的过程中,研究人员和临床医生研究了基因和细胞的变化如何与运动和认知功能有关。到目前为止,已经在中枢神经系统的许多区域发现了变化,现在已经知道,从出生前开始,不同的区域在生命过程中发生不同的变化。由于这些空间和时间的差异,必须考虑多种方法来解决运动和认知功能问题。
One of the overriding hopes of the Down syndrome (DS) research community is to arrive at a better understanding of how trisomy 21 affects brain development and function, and that doing so will improve quality of life and independence for people with DS. In searching for the underlying causes of intellectual disability in DS, researchers and clinicians have studied how changes to genes and cells may relate to motor and cognitive function. Thus far, alterations in many areas of the central nervous system have been found, and it is now known that, beginning before birth, different changes occur in different areas over the course of life. Because of these spatial and temporal variations, multiple approaches for addressing motor and cognitive function must be considered.
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