Natural suppressor (NS) cells, neonatal tolerance, and total lymphoid irradiation: exploring obscure relationships.
Natural suppressor (NS) cells, neonatal tolerance, and total lymphoid irradiation: exploring obscure relationships.
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DOI：
10.1146/annurev.iy.02.040184.001251
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发表时间：
1984
影响因子：
29.7
通讯作者：
S. Strober
中科院分区：
文献类型：
--
作者：
S. Strober
虽然几个实验室已经表明，自然发生的抑制细胞在新生儿或辐射小鼠的脾脏中的外观暂时与耐受诱导的容易性，这些细胞的特性和它们的调节功能一直知之甚少，直到最近。本文回顾的实验数据表明，这些细胞与NK细胞的表面表型有关，但功能不同。天然抑制（NS）细胞仅在淋巴组织早期成熟期间短暂出现，但可以通过使用某些治疗方案（例如全淋巴照射（TLI））操纵淋巴组织在成人中诱导。此外，NS细胞可以在长期组织培养中繁殖和克隆，从而允许对其性质进行更详细的研究。这些细胞具有抑制同种异体反应性免疫应答的抗原特异性细胞溶解臂的独特功能，但保留完整的抗原特异性抑制臂。以这种方式，在NS细胞的调节环境中的同种异体反应产生大量的抗原特异性抑制细胞，可以维持体内耐受。因此，NS细胞可能发挥重要作用，在发展中的宿主对移植物和移植物对宿主的耐受性在异基因骨髓嵌合体的耐受性的“窗口”期间，新生儿和TLI处理的小鼠接受输注的异基因细胞。
Although several laboratories have shown that the appearance of naturally occurring suppressor cells in the spleens of neonatal or irradiated mice is temporarily related to the ease of induction of tolerance, the characteristics of these cells and their regulatory functions have been poorly understood until recently. The experimental data reviewed herein suggests that these cells are related to NK cells with regard to surface phenotype but differ with regard to function. The natural suppressor (NS) cells appear only briefly during the early maturation of the lymphoid tissues but can be induced in adults by manipulation of the lymphoid tissues with certain treatment regimens such as total lymphoid irradiation (TLI). In addition, the NS cells can be propagated and cloned in long-term tissue culture, thereby allowing a more detailed investigation of their properties. The cells have the unique feature of inhibiting the antigen-specific cytolytic arm of alloreactive immune responses but leaving intact the antigen-specific suppressive arm. In this way, alloreactions in the regulatory milieu of NS cells generate large numbers of antigen-specific suppressor cells that can maintain tolerance in vivo. Thus the NS cells may play an important role in the development of host-vs-graft and graft-vs-host tolerance in allogeneic bone marrow chimeras during the "window" of tolerance in which neonate and TLI-treated mice accept the infused allogeneic cells.