PREVENTION OF THE ACUTE ETHANOL-INDUCED FATTY LIVER BY THE SIMULTANEOUS ADMINISTRATION OF ANTIOXIDANTS
PREVENTION OF THE ACUTE ETHANOL-INDUCED FATTY LIVER BY THE SIMULTANEOUS ADMINISTRATION OF ANTIOXIDANTS
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DOI：
10.1016/0024-3205(64)90189-4
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发表时间：
1964-01-01
期刊：
影响因子：
6.1
通讯作者：
DILUZIO, NR
中科院分区：
文献类型：
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作者：
DILUZIO, NR
已充分证明正常大鼠在服用乙醇后会出现脂肪肝 (1-5)。也有报道称，脂质耐受性受损会导致高甘油三酯血症 (4)。最近观察到，先给大鼠施用α-生育酚或NN-二苯酚-苯丙二胺(DPPD)，随后用乙醇治疗，分别可减少或完全预防脂肪肝(6)。本研究旨在确定某些其他抗氧化剂与乙醇同时施用是否也会抑制急性乙醇诱导的脂肪肝和高甘油三酯血症的发展。~实验雌性大鼠（Holtzman Co.，Madison，Wiac.）先前]，维持 Purina Chow 饮食，禁食 8 小时。然后动物通过口腔插管接受单剂量3g/Rg的50%(v/v)溶液形式的致醉剂量的乙醇，或等热量的葡萄糖。将乙醇和葡萄糖溶液与玉米油或油溶性抗#混合，部分得到 CD Sinither~a 基金会的资助，
The development of a fatty liver in normal rats following the administration of ethanol has been amply demonstrated (1-5). The occurrence of an impaired lipid tolerance, leading to hypertriglyceridemia, has also been reported (4). Recently it was observed that the prior administration of either a-tocopherol or NN-diphenpl-ppher~ plenediamine (DPPD) to rats subsequently treated with ethanol reduced or completely prevented, respectively, the fatty liver (6). The present study was undertaken to determine if the adminiistration of certain other antioxidants simultaneously with ethanol would also inhibit the development of the acute ethanol-induced fatty liver and hypertriglyceridemia.~ erimentalFemale rats (Holtzman Co., Madison, Wiac.) previous], y maintained on a Purina Chow diet were fasted for 8 hours. The animals then received by oral intubation, either a single intoxicating dose of ethanol in the amount of3g/Rg, as a 50~(v/v) solution, or a calorically equivalent amount of glucose. The ethanol and glucose solutions were mixed with corn oil or the oil soluble anti-# Supported in part by grant-in-aid from the CD Sinither~ a Foundation, the