Blebbing confers resistance against cell lysis
Blebbing confers resistance against cell lysis
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DOI：
10.1038/cdd.2010.81
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发表时间：
2011-01-01
影响因子：
12.4
通讯作者：
Draeger, A.
中科院分区：
文献类型：
--
作者：
Babiychuk, E. B.;Monastyrskaya, K.;Draeger, A.
质膜构成了维持细胞质和细胞外环境之间的本质差异的屏障。质膜损伤是许多细胞生命过程中的常见事件，通常导致其过早坏死性死亡。起泡-质膜突起的显示-是受损细胞的特征性特征。在这项研究中，我们揭示了一个以前未知的作用，水泡在家具抵抗质膜损伤。大泡作为损伤诱导的细胞内区室的前体，其捕获质膜的受损区段。因此，胞质溶胶的损失和细胞外成分的有害流入仅限于通过膜联蛋白A1 - a Ca（2+）-和膜结合蛋白塞与细胞体密封的泡。我们的发现揭示了一个有助于受损细胞存活的基本过程。通过靶向膜联蛋白A1/起泡，可以开发新的治疗方法来避免各种人类病理中细胞的坏死损失。Cell Death and Differentiation（2011）18，80-89; doi：10.1038/cdd.2010.81; 2010年7月2日在线发表
The plasma membrane constitutes a barrier that maintains the essential differences between the cytosol and the extracellular environment. Plasmalemmal injury is a common event during the life of many cells that often leads to their premature, necrotic death. Blebbing - a display of plasmalemmal protrusions - is a characteristic feature of injured cells. In this study, we disclose a previously unknown role for blebbing in furnishing resistance to plasmalemmal injury. Blebs serve as precursors for injury-induced intracellular compartments that trap damaged segments of the plasma membrane. Hence, loss of cytosol and the detrimental influx of extracellular constituents are confined to blebs that are sealed off from the cell body by plugs of annexin A1 - a Ca(2+)-and membrane-binding protein. Our findings shed light on a fundamental process that contributes to the survival of injured cells. By targeting annexin A1/blebbing, new therapeutic approaches could be developed to avert the necrotic loss of cells in a variety of human pathologies. Cell Death and Differentiation (2011) 18, 80-89; doi: 10.1038/cdd.2010.81; published online 2 July 2010