Coiled molecularly imprinted polymer layer open-tubular capillary tube for detection of parabens in personal care and cosmetic products
Coiled molecularly imprinted polymer layer open-tubular capillary tube for detection of parabens in personal care and cosmetic products
复制标题
用于检测个人护理和化妆品中对羟基苯甲酸酯的螺旋分子印迹聚合物层开管毛细管
DOI：
10.1016/j.scitotenv.2019.135961
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发表时间：
2020-03-01
影响因子：
9.8
通讯作者：
Jing, Tao
中科院分区：
文献类型：
--
作者：
Cheng, Ling;Huang, Kai;Jing, Tao
个人护理和化妆品（PCP）是人类接触对羟基苯甲酸酯的主要途径，其安全性已成为公众关注的问题。然而，由于PCP的复杂性和多样性，其样品前处理是一个巨大的挑战。以尼泊金乙酯为模板分子，甲基丙烯酸和异丁基乙烯基醚为共聚单体，甲基丙烯酸缩水甘油酯为后修饰单体，合成了环氧化合物修饰的分子印迹聚合物。通过对支化聚乙烯亚胺进行改性，将分子印迹聚合物接枝到聚四氟乙烯毛细管内表面，制备了分子印迹聚合物层开管。将该管盘绕以有效地增加质量传递，并与HPLC-UV系统偶联用于PCP中的对羟基苯甲酸酯检测。基质干扰显著降低，同时获得有效的富集和回收率。在优化的条件下，对羟基苯甲酸酯检测的线性范围为0.5-600 ng/mL，检出限为0.2 - 0.3 ng/mL。该系统用于研究流行的PCP中对羟基苯甲酸酯的含量。108种PCP中的对羟基苯甲酸酯浓度范围为
Personal care and cosmetic products (PCPs) are the primary exposure pathway of humans to parabens and their safety has become a public concern. However, sample pretreatment of PCPs is a great challenge due to their complexities and diversity. In this study, epoxide modified molecularly imprinted polymers (MIPs) were synthesized using ethylparaben as a template, methacrylic acid and isobutyl vinyl ether as co-monomers and glycidilmethacrylate as a post-modified monomer. MIP layer open-tubular tubes were prepared by modifying branched polyelhylenimine and then grafting MIPs onto the inner surface of Teflon capillary tubes. The tube was coiled to effectively increase mass transfer and coupled to an HPLC-UV system for parabens detection in PCPs. Matrix interference was significantly decreased while efficient enrichment and recoveries were obtained. Under optimized conditions, the linear range for parabens detection was 0.5-600 ng mL(-1) with detection limits of 0.2 to 0.3 ng mL(-1). The system was used to study the contents of parabens in popular PCPs. The concentrations of parabens in 108 PCPs ranged from