Predicting transporter‐mediated drug interactions: Commentary on: “Pharmacokinetic evaluation of a drug transporter cocktail consisting of digoxin, furosemide, metformin and rosuvastatin” and “Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporte
Predicting transporter‐mediated drug interactions: Commentary on: “Pharmacokinetic evaluation of a drug transporter cocktail consisting of digoxin, furosemide, metformin and rosuvastatin” and “Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporte
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预测转运蛋白介导的药物相互作用：评论：“由地高辛、呋塞米、二甲双胍和瑞舒伐他汀组成的药物转运蛋白混合物的药代动力学评估”和“用于药物转运临床药物相互作用评估的微剂量探针药物混合物的验证”
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Alex Sparreboom
中科院分区：
文献类型：
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作者：
L. Zhang;Alex Sparreboom
Transporters, expressed in various tissues, govern the absorption, distribution, metabolism, and excretion of drugs, and consequently their inherent safety and efficacy profiles. Drugs may interact with a transporter as a substrate and/or an inhibitor. Understanding transporter‐mediated drug‐drug interactions (DDIs), in addition to enzyme‐mediated DDIs, is an integral part of risk assessment in drug development and regulatory review because the concomitant use of more than one medication in patients is common.
