Experimental Observation of Giant Chiroptical Amplification of Small Chiral Molecules by Gold Nanosphere Clusters
Experimental Observation of Giant Chiroptical Amplification of Small Chiral Molecules by Gold Nanosphere Clusters
复制标题
金纳米球团簇对小手性分子的巨大手性光学放大的实验观察
DOI：
10.1021/jp5025813
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发表时间：
2014-05-08
影响因子：
3.7
通讯作者：
Zhang, Xiangdong
中科院分区：
文献类型：
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作者：
Wang, Rong-Yao;Wang, Peng;Zhang, Xiangdong
我们已经实验观察到约2个数量级的圆二色性（CD）增强在可见光区的半胱氨酸分子位于热点的金纳米球簇。所观察到的等离子体激元诱导的CD响应显示出显着的相关性，在热点分子的手性性质。这些结果提供了一个具体的实验演示预测的手旋光转移和放大效应，所产生的热点介导的激子-等离子体激元相互作用在强耦合的金属纳米结构，即使激子-等离子体激元耦合工作在远离共振制度。我们的研究结果表明，基于等离子体热点的CD放大器可能提供一种新的策略，超灵敏的检测和定量的分子手性的各种生物科学和生物医学应用的一个关键方面。
We have experimentally observed around 2 orders of magnitude circular dichroism (CD) enhancement in the visible region for cysteine molecules located in the hotspots of gold nanosphere clusters. The observed plasmon-induced CD responses show a significant correlation with the chiral nature of molecules at the hotspots. These results provide a concrete experimental demonstration on the predicted chiroptical transfer and amplification effect that arises from hotspot-mediated exciton–plasmon interactions in a strongly coupled metallic nanostructure, even though the exciton–plasmon coupling works at a far off-resonant regime. Our findings suggest here that plasmonic hotspot-based CD amplifier may provide a new strategy for ultrasensitive detection and quantification of molecular chirality—a key aspect for various bioscience and biomedicine applications.