Nitric oxide and clustering of metabolic syndrome components in pediatrics
Nitric oxide and clustering of metabolic syndrome components in pediatrics
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DOI：
10.1007/s10654-009-9382-3
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发表时间：
2010-01-01
影响因子：
13.6
通讯作者：
Azizi, Fereidoun
中科院分区：
文献类型：
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作者：
Ghasemi, Asghar;Zahediasl, Saleh;Azizi, Fereidoun
本研究旨在确定儿童和青少年代谢综合征（MetS）的危险因素模式与血清一氧化氮代谢产物（NO（x））的关系。该研究包括851名4-19岁的儿童和青少年。MetS根据修改的成人治疗组III标准定义。采用方差最大正交旋转主成分分析进行聚类分析，以检查代谢综合征的危险因素模式。男性和女性的MetS患病率分别为10.8%和10.0%。与下四分位数相比，上四分位数的NO（x）中MetS的性别和性别校正比值比显著更高（2.2，95% CI：1.1-4.7，p = 0.029）。在整个人群中，确定了三个因素，包括血压/肥胖，脂质/肥胖和葡萄糖/NO（x）。按性别分层，再次保留了三个因素;然而，在男性中，NO（x）加载在两个因素中。总之，在代谢危险因素的聚类分析中，血清NO（x）与其他MetS组分相关并负载。
This study was performed to determine the risk factor pattern of the metabolic syndrome (MetS) in association with serum nitric oxide metabolites (NO (x) ) in children and adolescents. The study included 851 children and adolescents, aged 4-19 years. The MetS was defined according to modified Adult treatment Panel III criteria. Cluster analysis was performed using principle components analysis with varimax orthogonal rotation to examine the risk factor pattern of the MetS. The prevalence of MetS was 10.8 and 10.0% in males and females, respectively. Age-and sex-adjusted odds ratio of having MetS was significantly higher in the upper quartile of NO (x) compared to the lower quartile (2.2, 95% CI: 1.1-4.7, p = 0.029). In the whole population, three factors were identified including blood pressure/obesity, lipid/obesity, and glucose/NO (x) . Stratifying for sex, again three factors were retained; however, in males NO (x) was loaded in two factors. In conclusion, serum NO (x) was associated and loaded with other MetS components in cluster analysis of metabolic risk factors.