Spontaneous nephrotic syndrome in a genetic rat model.
Spontaneous nephrotic syndrome in a genetic rat model.
复制标题
遗传大鼠模型中的自发性肾病综合征。
DOI：
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发表时间：
1984
影响因子：
6
通讯作者：
R. Snajdar
中科院分区：
文献类型：
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作者：
C. Abramowsky;M. Aikawa;G. Swinehart;R. Snajdar
我们对人类蛋白尿机制的理解的进展依赖于各种动物模型。大多数这些方法部分令人满意，因为它们需要用化学物质或毒素对动物进行预处理，或者它们依赖于与衰老相关的肾小球蛋白渗漏。本研究中的菌株是Koletsky在对一只高血压的Kyoto-Wistar大鼠和一只正常血压的Sprague-Dawley大鼠的后代进行选择性近交后获得的。受影响的动物出现在25%的窝中，表明常染色体隐性基因，并表现为自发性和进行性肾病综合征，早在3-5周检测到，并与肥胖、高血压、低白蛋白血症、高胆固醇血症和高脂血症相关。肾脏的初步形态学和免疫荧光研究显示进行性肾小球节段性硬化病变和突出的IgM系膜沉积，这一图像类似于人类特发性肾病综合征的类固醇抵抗形式，即局灶性肾小球硬化。
Advances in our understanding of the mechanisms of proteinuria in humans have depended on a variety of animal models. Most of these have been partially satisfactory because they require pretreatment of the animal with chemicals or toxins or they depend on an aging-related glomerular protein leakiness. The strain in this study was obtained by Koletsky after selective inbreeding of the offspring from a hypertensive Kyoto-Wistar and a normotensive Sprague-Dawley rat. The affected animals appear in 25% of the litters, indicating an autosomal recessive gene, and present with a spontaneous and progressive nephrotic syndrome detected as early as 3-5 weeks and associated with obesity, hypertension, hypoalbuminemia, hypercholesterolemia, and hyperlipidemia. Preliminary morphologic and immunofluorescence studies of their kidneys show progressive glomerular segmental sclerotic lesions and prominent mesangial deposition of IgM, a picture which resembles a steroid-resistant form of idiopathic nephrotic syndrome in humans, namely, focal glomerular sclerosis.
巨噬细胞在大鼠肾小球系膜摄取聚乙烯醇中的作用。
DOI：
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发表时间：
1983
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Seiler,MW;Hoyer,JR;Sterzel,RB
通讯作者：
Sterzel,RB