Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors.
Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors.
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DOI：
10.1016/j.neulet.2008.10.006
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发表时间：
2008-12-12
影响因子：
2.5
通讯作者：
Manev H
中科院分区：
文献类型：
--
作者：
Imbesi M;Uz T;Manev R;Sharma RP;Manev H
The tetracycline antibiotic minocycline beneficially affects neuronal functioning and also inhibits the enzyme 5-lipoxygenase (5-LOX). We hypothesized that similar to 5-LOX inhibitors, minocycline may increase phosphorylation and membrane insertion of the glutamate receptor GluR1. The experiments were performed in primary cultures of mouse striatal neurons and in the prefrontal cortex and striatum of minocycline-treated mice. Invitro, low micromolar minocycline concentrations increased GluR1 phosphorylation at Ser845 and Ser831 and increased the surface content of GluR1. Minocycline also increased GluR1 phosphorylation in-vivo. Increased GluR1 phosphorylation and minocycline treatmemt have been associated with antidepressant and memory-enhancing activities. Direct consequences of minocycline-increased GluR1 phosphorylation are yet to be established.
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影响因子：
3.4
作者：
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通讯作者：
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影响因子：
8.2
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.0600554103
发表时间：
2006-06-20
影响因子：
11.1
作者：
Alano, Conrad C.;Kauppinen, Tiina M.;Swanson, Raymond A.
通讯作者：
Swanson, Raymond A.