Sensorimotor Oscillatory Phase-Power Interaction Gates Resting Human Corticospinal Output
Sensorimotor Oscillatory Phase-Power Interaction Gates Resting Human Corticospinal Output
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DOI：
10.1093/cercor/bhy255
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发表时间：
2019-09-01
期刊：
影响因子：
3.7
通讯作者：
Cohen, Leonardo G.
中科院分区：
文献类型：
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作者：
Hussain, Sara J.;Claudino, Leonardo;Cohen, Leonardo G.
感觉运动网络中的振荡活动的特征是相变的相变变化。感觉运动振荡阶段与功率对人体运动功能（如皮质脊髓输出）之间的相互作用尚不清楚。我们通过在20名健康参与者的脑电图记录期间向人类运动皮层传递经颅磁刺激（TMS）来解决这一差距。电动机诱发电位是一种基于MU（8-12 Hz）和Beta（13-30 Hz）振荡阶段和功率在TMS时的电脊髓兴奋性的度量。使用试用的线性混合效应模型在连续的功率水平上评估皮质脊髓兴奋性的相位依赖性。对于MU，相位或功率没有影响（p> 0.51），而是X相的显着相互作用（P = 0.002）。随着MU功率水平的变化，相位依赖性的方向反向：在MU槽中，当MU功率较高时，在MU槽中的皮质脊髓输出较高，而当MU功率较低时相反。对于β振荡，没有类似的X功率相互作用（P> 0.11）。我们得出的结论是，感觉运动振荡阶段与功率闸门之间的相互作用在某种程度上无法通过感觉运动振荡阶段或功率来解释。
Oscillatory activity within sensorimotor networks is characterized by time-varying changes in phase and power. The influence of interactions between sensorimotor oscillatory phase and power on human motor function, like corticospinal output, is unknown. We addressed this gap in knowledge by delivering transcranial magnetic stimulation (TMS) to the human motor cortex during electroencephalography recordings in 20 healthy participants. Motor evoked potentials, a measure of corticospinal excitability, were categorized offline based on the mu (8-12 Hz) and beta (13-30 Hz) oscillatory phase and power at the time of TMS. Phase-dependency of corticospinal excitability was evaluated across a continuous range of power levels using trial-by-trial linear mixed-effects models. For mu, there was no effect of PHASE or POWER (P > 0.51), but a significant PHASE x POWER interaction (P = 0.002). The direction of phase-dependency reversed with changing mu power levels: corticospinal output was higher during mu troughs versus peaks when mu power was high while the opposite was true when mu power was low. A similar PHASE x POWER interaction was not present for beta oscillations (P > 0.11). We conclude that the interaction between sensorimotor oscillatory phase and power gates human corticospinal output to an extent unexplained by sensorimotor oscillatory phase or power alone.