Rh-I-Catalyzed Intramolecular [3+2] Cycloaddition of 1-Allene-vinylcyclopropanes
Rh-I-Catalyzed Intramolecular [3+2] Cycloaddition of 1-Allene-vinylcyclopropanes
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Rh-I 催化的 1-丙二烯-乙烯基环丙烷的分子内 [3 2] 环加成反应
DOI：
10.1002/ajoc.201800294
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发表时间：
2018
影响因子：
2.7
通讯作者：
Yu Zhi Xiang
中科院分区：
文献类型：
--
作者：
Liu Cheng Hang;Li Feng;Yuan Yuan;Dou Meng;Yu Zhi Xiang
铑催化的1-丙二烯-乙烯基环丙烷（1-allene-VCPs）的分子内[3+2]环加成反应以良好到优异的产率构建了在桥头位置具有季立体中心的环戊烷嵌入的双环结构。此外，这种转化也可以在减少催化剂负载的情况下大规模进行，这对于进一步的衍生化和应用是有用的。
A rhodium‐catalyzed intramolecular [3+2] cycloaddition of 1‐allene‐vinylcyclopropanes (1‐allene‐VCPs) to construct cyclopentane‐embedded bicyclic structures with quaternary stereocenters at the bridgehead position has been developed with good to excellent yields. In addition, this transformation could also be conducted on a large scale with reduced catalyst loading, which could be useful for further derivatizations and applications.