Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion
Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion
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DOI：
10.3892/or_00000897
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发表时间：
2010-09-01
期刊：
影响因子：
4.2
通讯作者：
Taguchi, Takashi
中科院分区：
文献类型：
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作者：
Nakayama, Toshyuki;Hirakawa, Hiroshi;Taguchi, Takashi
有强有力的证据表明血管生成素家族参与肿瘤进展、细胞生长和分化的调节。最近有报道称，癌细胞中的血管生成素样4（ANGPTL4）通过增加血管通透性来促进转移过程。为了阐明 ANGPTL4 表达及其与人胃腺癌临床病理因素和预后的关系，我们通过免疫组织化学检查了 103 例手术切除的人胃腺癌。 103例腺癌中，38例（36.9%）癌细胞胞质ANGPTL4呈阳性染色。组织学上，乳头状腺癌和粘液腺癌显示相对较高的 ANGPTL4 表达（分别为 60% 和 60%）。 ANGPTL4的表达与肿瘤侵袭深度相关（p
There is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth and differentiation. Recently, it has been reported that angiopoietin-like 4 (ANGPTL4) in cancer cell promotes the metastatic process by increasing vascular permeability. To elucidate ANGPTL4 expression and its association with clinicopathological factors and prognosis in human gastric adenocarcinomas, we examined 103 cases of surgically-resected human gastric adenocarcinoma by immunohistochemistry. Among 103 cases of adenocarcinoma, 38 cases (36.9%) showed positive staining in the cytoplasm of the carcinoma cells for ANGPTL4. Histologically, papillary and mucinous adenocarcinomas showed relatively high expression of ANGPTL4 (60 and 60%, respectively). The expression of ANGPTL4 was correlated with the depth of tumour invasion (p