Genetic evolution of swine influenza A (H3N2) viruses in China from 1970 to 2006
Genetic evolution of swine influenza A (H3N2) viruses in China from 1970 to 2006
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DOI：
10.1128/jcm.01257-07
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发表时间：
2008-03-01
影响因子：
9.4
通讯作者：
Tong, Guang-Zhi
中科院分区：
文献类型：
--
作者：
Yu, Hai;Hua, Rong-Hong;Tong, Guang-Zhi
猪对人类和禽流感病毒都敏感，因此被认为是通过重组或适应哺乳动物宿主而产生大流行性流感病毒的中间宿主或混合容器。本研究通过对1970 - 2006年中国发现的H3 N2亚型猪流感病毒的8个基因进行分析，首次总结并报道了中国猪群中完全类人H3 N2病毒、双重H3 N2病毒和三重H3 N2病毒共存的现象。1970年，第一个完全类似人的H3 N2（香港/68-like）病毒在台湾的猪中分离出来，然后在接下来的几年里，维多利亚/75-like，悉尼/97-like，纽约/99-like和莫斯科/99-like猪H3 N2病毒在中国定期分离出来。在20世纪80年代，从猪中分离出两种三重病毒。近年来，在我国猪群中出现了人源（HA和NA）和禽源（PB 2、PB 1、PA、NP、M和NS）的双重毒株以及人源（HA和NA）、猪源（NP）和禽源（PB 2、PB 1、PA、M和NS）的三重毒株。与人完全相似的病毒和疑似病毒的共存进一步证明了猪作为中间宿主或混合容器的作用，并强调了在中国加强猪流感病毒监测的重要性。
Pigs are susceptible to both human and avian influenza viruses and have been proposed to be intermediate hosts, or mixing vessels, for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we summarize and report for the first time the coexistence of wholly human-like H3N2 viruses, double-reassortant H3N2 viruses, and triple-reassortant H3N2 viruses in pigs in China by analyzing the eight genes of swine influenza A (H3N2) viruses found in China from 1970 to 2006. In 1970, the first wholly human-like H3N2 (Hong Kong/68-like) viruses were isolated from pigs in Taiwan, and then in the next years Victoria/75-like, Sydney/97-like, New York/99-like, and Moscow/99-like swine H3N2 viruses were regularly isolated in China. In the 1980s, two triple-reassortant viruses were isolated from pigs. Recently, the double-reassortant viruses containing genes from the human (HA and NA) and avian (PB2, PB1, PA, NP, M, and NS) lineages and the triple-reassortant viruses containing genes from the human (HA and NA), classical swine (NP), and avian (PB2, PB1, PA, M, and NS) lineages emerged in pigs in China. The coexistence of wholly human-like and reassortant viruses provides further evidence that pigs serve as intermediate hosts, or mixing vessels, and emphasizes the importance of reinforcing swine influenza virus surveillance in China.