Physiologic Parameters as Biomarkers: What Can We Learn from Physiologic Variables and Variation?
Physiologic Parameters as Biomarkers: What Can We Learn from Physiologic Variables and Variation?
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DOI：
10.1016/j.ccc.2010.12.008
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发表时间：
2011-04-01
影响因子：
4.3
通讯作者：
Artigas, Antonio
中科院分区：
文献类型：
--
作者：
Ferrer, Ricard;Artigas, Antonio
脓毒症产生以生理参数变化为特征的压倒性宿主反应。监测这些参数可以帮助识别和分层脓毒症患者。早期识别脓毒症并识别有恶化风险的脓毒症患者是成功治疗的关键。几项研究分析了与脓毒症或菌血症诊断、严重脓毒症或脓毒性休克发展以及死亡率相关的独立生理参数。脓毒症患者心率和体温的生理变异性降低，测量这些参数的变异性可用于脓毒症的诊断和预后。
Sepsis generates an overwhelming host response characterized by changes in physiologic parameters. Monitoring these parameters can help identify and stratify septic patients. Recognizing sepsis early and identifying septic patients at risk of worsening are keys to successful treatment. Several studies have analyzed the independent physiologic parameters associated with the diagnosis of sepsis or bacteremia, with the development of severe sepsis or septic shock, and with mortality. Physiologic variability of heart rate and body temperature is reduced in sepsis and measuring the variability of these parameters can be useful for the diagnosis and prognosis of sepsis.