Concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from Greenland
Concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from Greenland
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DOI：
10.2307/3454581
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发表时间：
1999-10-01
影响因子：
10.4
通讯作者：
Hansen, JC
中科院分区：
文献类型：
--
作者：
Dewailly, É;Mulvad, G;Hansen, JC
有机氯是一种持久性亲脂性化合物，在生活在环极地国家的因纽特人体内积累。因纽特人大量食用海洋哺乳动物脂肪，导致有机氯积累；然而，现有数据仅限于血脂、乳脂和脂肪组织。我们报告了 1992 年至 1994 年间从已故格陵兰人身上采集的肝脏、大脑、网膜脂肪和皮下腹部脂肪样本中有机氯的测定结果。通过电子捕获检测高分辨率气相色谱法测定了组织脂质提取物中的 11 种氯化农药和 14 种多氯联苯同系物。格陵兰人脂肪组织样本中多氯联苯、2,2'-双(4-氯苯基)-1,1-二氯乙烯、β-六氯环己烷、六氯苯、灭蚁灵、反式九氯和氯丹的平均浓度比使用相同分析方法在魁北克省魁北克市加拿大人样本中测得的浓度高3-34倍。脑脂质中所有有机氯的浓度低于从其他组织提取的脂质。肝脏、网膜脂肪和腹部皮下脂肪样品的脂质提取物中的有机氯残留水平相似，但对六氯环己烷除外，其在肝脏脂质中的浓度高于两种脂肪组织脂质中的浓度（4倍；p < 0.05）。与现有的国际脂肪组织水平数据比较表明，格陵兰因纽特人体内有机氯负担目前是环境暴露造成的最高之一。
Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits' large consumption of sea mammal fat; however, available data are limited to blood lipids, milk fat, and adipose tissue. We report results of organochlorine determination in liver, brain, omental fat, and subcutaneous abdominal fat samples collected from deceased Greenlanders between 1992 and 1994. Eleven chlorinated pesticides and 14 polychlorinated biphenyl congeners were measured in tissue lipid extracts by high-resolution gas chromatography with electron capture detection. Mean concentrations of polychlorinated biphenyls, 2,2'-bis(4-chlorophenyl)-1,1-dichloroethylene, beta-hexachlorocyclohexane, hexachlorobenzene, mirex, trans-nonachlor, and oxychlordane in adipose tissue samples from Greenlanders were 3-34-fold higher than those measured using the same analytical method in samples from Canadians in Quebec City, Quebec. Brain lipids contained lower concentrations of all organochlorines than lipids extracted from other tissues. Organochlorine residue levels in lipid extracts from liver, omenta fat, and subcutaneous abdominal fat samples were similar, with the exception of P-hexachlorocyclohexane, which reached a greater concentration in liver lipids than in lipids from both adipose tissues (4-fold; p < 0.05). Comparisons with available international data on adipose tissue levels reveal that the organochlorine body burden in the Inuit population of Greenland is presently among the highest resulting from environmental exposure.