The interleukin-1 system: Receptors, ligands, and ICE in the brain and their involvement in the fever response
The interleukin-1 system: Receptors, ligands, and ICE in the brain and their involvement in the fever response
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DOI：
10.1111/j.1749-6632.1998.tb09548.x
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发表时间：
1998-01-01
影响因子：
2.4
通讯作者：
Bartfai, T
中科院分区：
文献类型：
--
作者：
Alheim, K;Bartfai, T
白细胞介素1 （IL-1）系统的配体和受体构成了一组高度诱导的蛋白，其在感染和炎症中的表达在宿主防御中起着至关重要的作用。IL-1系统参与刺激免疫系统、神经内分泌系统和神经免疫系统。该系统的主要可溶性和分泌性激动剂IL-1 β已通过突变和转基因方法进行了研究。此外，通过零突变技术研究了信号转导I型IL-1受体（IL-1RI）在发烧和其他反应中的作用。我们描述了两种激动剂IL-1 α （31 kDa和17 kDa）和IL-1 β (17 kDa)（1,2）以及IL-1受体亚型IL-1RI和IL-1RII(3)在大脑和肾上腺（以及垂体细胞系AtT20）中的诱导表达。我们还描述了IL-1家族的另一个成员：IL-1受体拮抗剂（IL-1ra），(4)内源性IL-1 α和IL-1 β拮抗剂。此外，还讨论了IL-1 β转换酶（ICE）及其在脑和肾上腺中的差异调控和表达。(5)发热是对IL-1 β或IL-1 β腹腔或脑室注射的全身性反应。IL-1ra预处理可阻断IL-1 β诱导的发热。(6)根据对IL-1 β受体亚型特异性突变体的研究(7)和对IL-1RI敲除（IL-1RI KO）小鼠的研究推断，发热反应似乎是通过IL-1RI介导的。(8) IL-1 β敲除小鼠对IL-1激动剂、IL-1 α和IL-1 β以及LPS均表现出高反应性发热。
The ligands and the receptors of the interleukin 1 (IL-1) system constitute a highly inducible set of proteins whose expression in infection and inflammation is of key importance in the host defense. The IL-1 system participates in the stimulation of the immune system, the neuroendocrine system, and the neuroimmune system. The major soluble and secreted agonist of the system, IL-1 beta, has been studied by mutational and transgenic approaches. Furthermore, involvement of the signal-transducing type I IL-1 receptor (IL-1RI), in fever and other responses, has been studied by null mutation technique. We describe the inducible expression of the two agonists, IL-1 alpha (31 kDa and 17 kDa) and IL-1 beta (17 kDa)(1,2) and of the IL-1 receptor subtypes IL-1RI and IL-1RII(3) in the brain and in the adrenals (as well as in the pituitary cell line AtT20). We also describe an additional member of the IL-1 family: the IL-1 receptor antagonist (IL-1ra),(4) an endogenous antagonist to IL-1 alpha and IL-1 beta. Furthermore, the IL-1 beta-converting enzyme (ICE) and its differential regulation and expression in brain and adrenals is also discussed.(5) Fever is a systemic response to intraperitoneal (i.p.) or inh acerebroventricular (i.c.v.) injection of IL-1 beta or IL-1 beta. IL-1 beta-induced fever can be blocked by IL-1ra pretreatment.(6) The fever response seems to be mediated via the IL-1RI as inferred from studies with receptor subtype-specific mutants of IL-1 beta(7) and from studies in IL-1RI knock-out (IL-1RI KO) mice.(8) IL-1 beta knock-out mice showed a hyperresponsive fever to both IL-1 agonists, IL-1 alpha, and IL-1 beta, as well as to LPS.(2).