Study of osteoporosis treatment principles used historically by ancient physicians in Chinese Medicine
Study of osteoporosis treatment principles used historically by ancient physicians in Chinese Medicine
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DOI：
10.1007/s11655-013-1328-z
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发表时间：
2013-11-01
影响因子：
2.9
通讯作者：
Xu Dan
中科院分区：
文献类型：
--
作者：
Gao Zhen;Lu Yong;Xu Dan
回顾历史上最常用于治疗骨质疏松症的草药；研究其性味、归经；利用《中医经典》（升级版）光盘检索治疗骨质疏松症的历史方剂，并进行收集整理。通过聚类分析确定药性、味味、归经归属，确定用药规律。共查出处方389张，涉及药物238种，总出现次数4236次。常用药物有牛膝、熟地、肉桂、杜仲、茯苓、肉苁蓉、附子、当归等。使用的药材共有五种属性，总共出现了2499次；最常见的两种是温暖和朴素。药味有7种，出现4151次；甜味和苦味是最常见的两种。识别出8条经络归属，共出现6374次；肾经和肝经是最常见的两个经络。最常见的功能类别是补阳药和补血药，合计占总数的37.8%。 28种最常用的中药形成3个处方簇：C1：杜仲、茯苓、牛膝； C2:杜仲、茯苓、牛膝、肉桂、熟地、肉苁蓉、当归、附子、菟丝子； C3：虎骨、白术、桑葚、当归、白芍、石斛、泽泻、山茱萸、防风。虚是骨质疏松的首要病机，“瘀”、水血不流通。临床治疗骨质疏松症应以补肾、肝、脾为主，利水化瘀为辅，同时注意调整精神。
To review the herbal drugs most often used throughout history for the treatment of osteoporosis; to study their property, flavor and meridian attribution; and to explore their compatibility.The "Chinese Medical Classics" (upgrade) CD-ROM was used to retrieve historical prescriptions for the treatment of osteoporosis, and these were collected and sorted. Property, flavor and meridian attribution were determined, and the rules of herbal administration were determined by cluster analysis.A total of 389 prescriptions were found, involving 238 herbal drugs, with a total frequency of appearance of 4,236. Commonly used medications were Radix Achyranthis Bidentatae, Radix Rehmanniae praeparata, Cortex Cinnamomi, Cortex Eucommiae, Poria, Herba Cistanches, Radix Aconiti lateralis and Radix Angelicae sinensis. The herbs used included five kinds of properties, appearing a total of 2,499 times; the two most common ones were warm and plain. There were seven different drug flavors, occurring 4,151 times; sweet and bitter were the two most common ones. Eight meridian attributions were identified, appearing a total of 6,374 times; Kidney (Shen)-meridian and Liver (Gan)-meridian were the two most common ones. The most common functional categories were yang-tonifying medicinal and blood-tonifying medicinal, and together these accounted for 37.8% of the total. The twenty-eight most commonly used herbal drugs formed 3 prescription clusters: C1: Cortex Eucommiae, Poria, Radix Achyranthis Bidentatae; C2: Cortex Eucommiae, Poria, Radix Achyranthis Bidentatae, Cortex Cinnamomi, Radix Rehmanniae praeparata, Herba Cistanches, Radix Angelicae sinensis, Radix Aconiti lateralis, Semen Cuscutae; C3: Os Tigris, Rhizoma Atractylodes Alba, Radix Moromdae Officinalis, Radix Angelicae pubescentis, Radix Paeoniae Alba, Herba Dendrobii, Rhizoma Alismatis, Fructus Corni, Radix Saposhnikoviae.Deficiency is the primary pathogenetic factor in osteoporosis, along with "stagnation" and lack of flow of water or blood. Clinical treatment of osteoporosis should be based on Kidney, Liver and Spleen (Pi) supplementation, and complemented by diuresis and dissolution of stasis, while paying attention to adjustment of the spirit.