Metal‐Ion‐Mediated Base Pairs in Nucleic Acids (Eur. J. Inorg. Chem. 24/2008)
Metal‐Ion‐Mediated Base Pairs in Nucleic Acids (Eur. J. Inorg. Chem. 24/2008)
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DOI：
10.1002/ejic.200890065
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发表时间：
2008-08
影响因子：
2.3
通讯作者：
Jens Müller
中科院分区：
文献类型：
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作者：
Jens Müller
封面图片显示了用金属离子位点特异性官能化的核酸的实例。这是通过掺入对金属离子具有高亲和力的人工核苷来实现的，这导致形成金属离子介导的碱基对。左边的示意图是包含天然和人工碱基对的B型双螺旋的表示。中间显示的是含有金属离子介导的碱基对的连续堆叠的双链体，而右边的方案显示了使用这些人工核苷形成基于DNA的网络的可能性。Jens Muller在第3749页的微评论介绍了生物无机化学这一令人兴奋的新领域。我们感谢多米尼克A。高阻表设计封面图片。
The cover picture shows examples of nucleic acids functionalized site-specifically with metal ions. This was achieved by incorporating artificial nucleosides with a high affinity towards metal ions, which leads to the formation of metal-ion-mediated base pairs. The scheme on the left is a representation of a B-type double helix comprising both natural and artificial base pairs. Shown in the middle is a duplex containing a continuous stack of metal-ion-mediated base pairs, whereas the scheme on the right displays the possibility of using these artificial nucleosides for the formation of DNA-based networks. The Microreview by Jens Muller on p. 3749 ff gives an introduction into this exciting new area of bioinorganic chemistry. We thank Dominik A. Megger for designing the cover picture.